Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUOFM4)

• Drug Name: Sernivo Drug Info
• Synonyms: Diprosone; Diprolene; Diprolene AF; Maxivate; Diproderm; Diprosis; Alphatrex; Psorion; 5593-20-4; Rinderon DP; Betamethasone-17,21-dipropionate; Betamethasone 17,21-dipropionate; Sch-11460; Sch 11460; UNII-826Y60901U; beta-Methasone 17,21-dipropionate; EINECS 227-005-2; S-3440; BRN 3638108; CHEBI:31276; CIWBQSYVNNPZIQ-XYWKZLDCSA-N; S 3440; 826Y60901U; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-dien
• Cross-matching ID:
  PubChem CID: 21800
  ChEBI ID: CHEMBL31276
  CAS Number: CAS 5593-20-4
  TTD Drug ID: D0MD6C

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Collecting duct acid secretion	2.08	1.05e-2	22/27 (81.48%)	ATP6V0E1;ATP6V0A4;ATP6V1B1;...
Cholesterol metabolism	1.78	4.53e-2	44/50 (88%)	NPC2;LDLRAP1;APOC1;...
Riboflavin metabolism	1.77	4.33e-2	7/8 (87.5%)	ENPP1;ACP5;BLVRB;...
N-Glycan biosynthesis	1.74	4.84e-2	38/50 (76%)	GANAB;MAN1A1;ST6GAL1;...
Cysteine and methionine metabolism	-1.70	4.40e-2	43/50 (86%)	MTAP;SRM;GOT2;...
Linoleic acid metabolism	-1.70	4.78e-2	21/29 (72.41%)	PLA2G4A;CYP2C8;PLA2G10;...
Malaria	-1.75	3.23e-2	44/50 (88%)	CD81;IL6;CD40;...
Hypertrophic cardiomyopathy	-1.77	3.14e-2	81/90 (90%)	SGCG;ITGA6;SGCD;...
Retinol metabolism	-1.77	3.66e-2	41/68 (60.29%)	CYP2C8;ADH1C;ALDH1A2;...
Renin-angiotensin system	-1.83	2.10e-2	20/23 (86.96%)	KLK2;CTSG;AGT;...
Rheumatoid arthritis	-1.91	7.17e-3	78/93 (83.87%)	IL23A;TNF;TGFB2;...
IL-17 signaling pathway	-2.00	0.00e+0	84/94 (89.36%)	CCL11;TNF;LCN2;...
Legionellosis	-2.01	0.00e+0	51/57 (89.47%)	IL6;HBS1L;CASP7;...
Pertussis	-2.29	0.00e+0	64/76 (84.21%)	NFKB1;C1R;MAPK11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲