Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUPE07)

• Drug Name: Nicotinamide Drug Info
• Synonyms: Aminicotin; Amixicotyn; Amnicotin; Benicot; Dipegyl; Endobion; Enduramide; Hansamid; Mediatric; Niacevit; Niacinamide; Niacotinamide; Niamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamidum; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nikasan; Nikazan; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; Papulex; Pelmin; Pelmine; Savacotyl; Amid kyseliny nikotinove; Amid kyseliny nikotinove [Czech]; Amide PP; Astra Brand of Niacinamide; Austrovit PP; Delonin amide; Factor pp; Inovitan PP; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Niacinamide [USAN]; Niavit PP; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaureamid Jenapharm; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Pelonin amide; Pharmagenix Brand of Niacinamide; Vitamin B; Vitamin PP; Witamina PP; Nicosan 2; Vitamin H1; B 3, Vitamin; B3, Vitamin; Beta-Pyridinecarboxamide; Jenapharm, Nicotinsaureamid; Nandervit-N; Niacin-Vitamin B3; Niacinamide (USP); Nicotinamida [INN-Spanish]; Nicotinamide (Niacinamide); Nicotinamidum [INN-Latin]; Niko-tamin; PP-Faktor; Vi-Nicotyl; Vitamin B (VAN); M-(Aminocarbonyl)pyridine; Niacinamide, Nicotinic acid amide, Nicotinamide; Nicotinamide (JP15/INN); Nicotinamide, niacin, vitamin B3; Nicotinamide-carbonyl-14C; Pyridine-3-carboxamide; Pyridine-3-carboxylic acid amide; 3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 936
  ChEBI ID: CHEMBL17154
  CAS Number: CAS 98-92-0
  TTD Drug ID: D06NVJ
  INTEDE Drug ID: DR1147

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.38	0.00e+0	113/158 (71.52%)	MRPS16;RPL29;RPS25;...
DNA replication	2.21	0.00e+0	34/36 (94.44%)	PCNA;PRIM1;RFC5;...
RNA transport	2.19	0.00e+0	128/186 (68.82%)	EIF2S3;NXT2;NUP107;...
Proteasome	2.10	0.00e+0	44/46 (95.65%)	PSMD6;PSMD4;POMP;...
Legionellosis	2.00	4.07e-3	51/57 (89.47%)	CXCL8;C3;CXCL2;...
IL-17 signaling pathway	1.89	1.19e-2	84/94 (89.36%)	CXCL8;MMP1;CXCL2;...
Parkinson disease	1.88	1.16e-2	176/249 (70.68%)	DAXX;PSMD6;TUBB2A;...
Nucleotide excision repair	1.84	1.40e-2	40/47 (85.11%)	PCNA;RFC5;POLE2;...
Antigen processing and presentation	1.82	1.70e-2	60/78 (76.92%)	HSP90AA1;HSPA4;HLA-DRB1;...
Coronavirus disease	1.78	2.44e-2	215/232 (92.67%)	CXCL8;MMP1;C3;...
Mismatch repair	1.78	2.31e-2	22/23 (95.65%)	PCNA;RFC5;LIG1;...
Prion disease	1.77	2.12e-2	209/273 (76.56%)	PSMD6;TUBB2A;SOD1;...
Amyotrophic lateral sclerosis	1.75	2.19e-2	267/364 (73.35%)	DAXX;NXT2;PSMD6;...
Huntington disease	1.72	2.62e-2	233/306 (76.14%)	PSMD6;TUBB2A;SOD1;...
Spliceosome	1.71	2.92e-2	101/150 (67.33%)	SRSF1;HSPA8;EIF4A3;...
Lipid and atherosclerosis	1.67	4.14e-2	190/215 (88.37%)	CXCL8;MMP1;CXCL2;...
Base excision repair	1.66	4.31e-2	29/33 (87.88%)	PCNA;POLE2;LIG1;...
Aminoacyl-tRNA biosynthesis	1.66	4.24e-2	15/66 (22.73%)	IARS2;LARS2;GATC;...
Mineral absorption	1.65	4.34e-2	48/60 (80%)	MT1E;MT1G;MT1H;...
Citrate cycle (TCA cycle)	1.64	4.33e-2	30/30 (100%)	DLST;DLD;PDHA1;...
Renin-angiotensin system	1.63	4.90e-2	20/23 (86.96%)	ACE2;ANPEP;AGTR1;...
Cell cycle	1.62	4.95e-2	110/124 (88.71%)	CDKN2C;PCNA;TFDP1;...
Steroid biosynthesis	-2.06	0.00e+0	19/20 (95%)	SOAT1;FDFT1;LSS;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	25uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼