Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUPN01)

• Drug Name: AR-A014418 Drug Info
• Synonyms: 487021-52-3; GSK-3beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; A Inhibitor VIII; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; UNII-87KSH90Q6D; AR-AO 14418; SN 4521; AR-A 014418; CHEMBL259850; 87KSH90Q6D; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AK175829; C12H12N4O4S; N-(4-Methoxybenzyl)-N& -(5-nitro-1,3-thiazol-2-yl)urea; AR 014418; GSK 3be
• Cross-matching ID:
  PubChem CID: 448014
  ChEBI ID: CHEMBL259850
  CAS Number: CAS 487021-52-3
  TTD Drug ID: D0A3MV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	1.99	0.00e+0	52/108 (48.15%)	GTPBP4;PWP2;NMD3;...
Spliceosome	1.87	4.86e-2	101/150 (67.33%)	CHERP;SRSF10;PRPF19;...
Epithelial cell signaling in Helicobacter pylori infect...	1.86	3.64e-2	62/70 (88.57%)	ATP6V1D;MET;CDC42;...
Oocyte meiosis	1.85	3.34e-2	90/129 (69.77%)	AURKA;PLK1;MAPK1;...
Progesterone-mediated oocyte maturation	1.82	4.13e-2	75/100 (75%)	AURKA;PLK1;MAPK1;...
Cell cycle	1.82	3.44e-2	110/124 (88.71%)	CCND1;PLK1;TGFB2;...
Rheumatoid arthritis	1.79	3.82e-2	78/93 (83.87%)	ATP6V1D;CCL2;TGFB2;...
AGE-RAGE signaling pathway in diabetic complications	1.78	3.34e-2	97/100 (97%)	TGFBR2;THBD;CCND1;...
Malaria	1.76	3.78e-2	44/50 (88%)	SDC2;CD36;MET;...
Collecting duct acid secretion	1.74	4.01e-2	22/27 (81.48%)	ATP6V1D;CA2;SLC4A1;...
Colorectal cancer	1.72	4.30e-2	84/86 (97.67%)	EREG;AREG;TGFBR2;...
DNA replication	1.72	4.15e-2	34/36 (94.44%)	POLE3;MCM3;RFC3;...
Cushing syndrome	-1.68	4.94e-2	125/155 (80.65%)	CACNA1H;AXIN1;EGFR;...
Ferroptosis	-1.74	2.41e-2	36/41 (87.8%)	ATG7;ACSL3;ACSL1;...
Biosynthesis of unsaturated fatty acids	-1.76	2.16e-2	21/27 (77.78%)	ELOVL2;ACOX1;HSD17B12;...
Cortisol synthesis and secretion	-1.77	2.38e-2	58/65 (89.23%)	ATF2;NR0B1;ADCY9;...
Ovarian steroidogenesis	-1.83	1.68e-2	41/51 (80.39%)	ADCY9;CYP17A1;AKR1C3;...
Protein digestion and absorption	-1.91	4.19e-3	78/103 (75.73%)	ATP1B2;SLC7A8;COL9A2;...
Salivary secretion	-1.93	2.80e-3	76/93 (81.72%)	ITPR3;BST1;CHRM3;...
Protein processing in endoplasmic reticulum	-2.24	0.00e+0	127/171 (74.27%)	P4HB;VCP;EIF2AK2;...
Steroid biosynthesis	-2.42	0.00e+0	19/20 (95%)	EBP;TM7SF2;HSD17B7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	15uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	3.33uM - 10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	2.5uM - 10uM	6H, 24H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	2.5uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	3.33uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	3.33uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	3.33uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	3.33uM - 10uM	6H	Show ▼