Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUR64T)

Drug Name
Lesinurad Drug Info
Synonyms
LESINURAD; 878672-00-5; RDEA594; Zurampic; RDEA 594; UNII-09ERP08I3W; RDEA-594; 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid; 09ERP08I3W; AK323774; C17H14BrN3O2S; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid; 2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid
Cross-matching ID
PubChem CID
53465279
ChEBI ID
CHEMBL2105720
CAS Number
CAS 878672-00-5
TTD Drug ID
D0C3SW
VARIDT Drug ID
DR01130
INTEDE Drug ID
DR0926
ACDINA Drug ID
D00354

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Graft-versus-host disease 2.24 0.00e+0 32/42 (76.19%) GZMB;HLA-DRA;HLA-DRB1;...
Allograft rejection 2.12 0.00e+0 32/38 (84.21%) GZMB;HLA-DRA;HLA-DRB1;...
Citrate cycle (TCA cycle) 2.05 0.00e+0 30/30 (100%) DLD;OGDH;SDHA;...
Type I diabetes mellitus 2.04 0.00e+0 38/43 (88.37%) GZMB;HLA-DRA;HLA-DRB1;...
Insulin secretion 1.90 4.19e-3 75/86 (87.21%) SNAP25;CREB1;ADCY1;...
Viral protein interaction with cytokine and cytokine re... 1.88 3.49e-3 84/100 (84%) CCL5;CXCL9;CXCL13;...
Autoimmune thyroid disease 1.82 1.20e-2 46/53 (86.79%) GZMB;HLA-DRA;HLA-DRB1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.81 1.44e-2 49/53 (92.45%) ATP2B4;KLK2;AP2A2;...
Systemic lupus erythematosus 1.80 1.51e-2 45/135 (33.33%) HLA-DRA;C1R;C1S;...
Oocyte meiosis 1.75 2.72e-2 90/129 (69.77%) ADCY1;CCNB2;PPP3CB;...
Circadian entrainment 1.73 3.24e-2 85/97 (87.63%) CREB1;ADCY1;GRIA2;...
Tryptophan metabolism 1.73 2.97e-2 35/42 (83.33%) DLD;MAOA;DHTKD1;...
Antigen processing and presentation 1.72 2.90e-2 60/78 (76.92%) CREB1;CD74;PDIA3;...
Chemokine signaling pathway 1.72 2.77e-2 163/192 (84.9%) CCL5;CXCL9;CXCL13;...
Dopaminergic synapse 1.69 3.70e-2 115/132 (87.12%) MAOA;CREB1;PPP3CB;...
Th1 and Th2 cell differentiation 1.67 4.38e-2 80/92 (86.96%) IL2RB;PPP3CB;HLA-DRA;...
Pancreatic secretion 1.65 4.50e-2 87/102 (85.29%) CPB1;ATP2B4;ADCY1;...
Long-term potentiation 1.65 4.89e-2 61/67 (91.04%) ADCY1;PPP3CB;GRIA2;...
Human cytomegalovirus infection 1.65 4.63e-2 201/225 (89.33%) CCL5;PTGER4;NFATC4;...
Legionellosis -1.84 3.17e-2 51/57 (89.47%) SAR1A;CR1;NFKB2;...
Oxidative phosphorylation -1.85 3.33e-2 93/133 (69.92%) ATP5ME;LHPP;NDUFA8;...
Ribosome -2.00 9.52e-3 113/158 (71.52%) RPS24;RPS29;MRPS11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 2.22uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H