Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMURH4X)

Drug Name
Oxypurinol Drug Info
Synonyms Oxypurinol (intravenous)
Cross-matching ID
PubChem CID
135398752
ChEBI ID
CHEMBL859
CAS Number
CAS 2465-59-0
TTD Drug ID
D08FWK
VARIDT Drug ID
DR00123

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA degradation 1.91 2.55e-2 53/79 (67.09%) TOB1;PFKL;EXOSC9;...
RIG-I-like receptor signaling pathway 1.87 1.70e-2 64/70 (91.43%) CXCL8;IKBKE;ISG15;...
Herpes simplex virus 1 infection 1.85 2.27e-2 165/498 (33.13%) IKBKE;TICAM1;TP53;...
Epstein-Barr virus infection 1.79 2.55e-2 189/202 (93.56%) IKBKE;E2F2;ISG15;...
Hepatitis C 1.78 2.55e-2 139/157 (88.54%) IFIT1;IKBKE;E2F2;...
Measles 1.76 2.69e-2 133/139 (95.68%) IKBKE;TNFAIP3;TP53;...
Ribosome 1.76 2.31e-2 113/158 (71.52%) MRPS2;MRPS16;RPS4Y1;...
IL-17 signaling pathway 1.72 3.19e-2 84/94 (89.36%) CXCL8;S100A7;IKBKE;...
Influenza A 1.71 3.59e-2 156/172 (90.7%) CXCL8;IKBKE;TICAM1;...
Salivary secretion -1.64 4.84e-2 76/93 (81.72%) BEST2;PRKCB;GNAQ;...
African trypanosomiasis -1.67 3.61e-2 32/37 (86.49%) IL6;PRKCB;IL18;...
Arachidonic acid metabolism -1.69 3.46e-2 48/61 (78.69%) CYP2B6;CYP2C8;PLA2G12A;...
Pancreatic secretion -1.69 3.47e-2 87/102 (85.29%) KCNMA1;PLCB3;SLC9A1;...
Adherens junction -1.70 3.11e-2 63/71 (88.73%) MAP3K7;AFDN;NLK;...
Pyruvate metabolism -1.72 2.52e-2 41/47 (87.23%) GLO1;ACAT1;FH;...
Aldosterone synthesis and secretion -1.74 2.13e-2 85/98 (86.73%) ATP1A3;PRKACA;CREB3;...
Mucin type O-glycan biosynthesis -1.76 1.68e-2 20/36 (55.56%) GALNT8;GALNT12;GALNT1;...
Renin-angiotensin system -1.77 1.57e-2 20/23 (86.96%) ANPEP;ENPEP;AGT;...
Arginine biosynthesis -1.78 1.35e-2 17/22 (77.27%) NOS2;ASL;GLUL;...
Mineral absorption -1.78 1.37e-2 48/60 (80%) HMOX1;ATP7A;SLC26A6;...
Cortisol synthesis and secretion -1.79 9.98e-3 58/65 (89.23%) PRKACA;CREB3;CREB5;...
ABC transporters -1.79 1.10e-2 37/45 (82.22%) ABCC2;ABCA8;ABCG4;...
Metabolism of xenobiotics by cytochrome P450 -1.80 1.10e-2 49/77 (63.64%) GSTM5;UGT2B15;UGT2A3;...
Protein digestion and absorption -1.87 8.23e-3 78/103 (75.73%) COL17A1;KCNK5;COL6A2;...
Bile secretion -1.88 7.84e-3 68/90 (75.56%) ATP1A3;PRKACA;ABCC2;...
Focal adhesion -1.94 1.83e-3 180/201 (89.55%) ITGAV;PAK5;SOS1;...
Drug metabolism -1.95 2.20e-3 78/151 (51.66%) IMPDH1;GSTM5;DPYS;...
ECM-receptor interaction -1.96 2.74e-3 80/88 (90.91%) ITGA3;ITGA9;COL9A1;...
Steroid hormone biosynthesis -2.02 3.66e-3 43/61 (70.49%) UGT2B15;UGT2A3;STS;...
Retinol metabolism -2.16 0.00e+0 41/68 (60.29%) UGT2B15;UGT2A3;CYP3A5;...
Complement and coagulation cascades -2.25 0.00e+0 76/85 (89.41%) C8A;VWF;CFHR4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H