Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUXP52)

• Drug Name: Clobetasol Drug Info
• Synonyms: Clobetasolum; Clofenazon; Clobecort Amex; Butavate (TN); Clobecort Amex (TN); Clobetasol (INN); Clobetasol [INN:BAN]; Clobetasolum [INN-Latin]; Clobex (TN); Dermatovate (TN); Dermovate (TN); Movate (TN); Olux (TN); Temovate (TN); Tenovate (TN); (11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; (9R,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; 21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 5311051
  ChEBI ID: CHEMBL205919
  CAS Number: CAS 25122-41-2
  TTD Drug ID: D0FL5V

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.31	0.00e+0	76/85 (89.41%)	C3;F3;F13A1;...
Chronic myeloid leukemia	2.07	0.00e+0	72/76 (94.74%)	NFKBIA;TGFBR2;GADD45B;...
Non-alcoholic fatty liver disease	2.05	0.00e+0	126/155 (81.29%)	IRS2;PIK3R1;IL6R;...
Diabetic cardiomyopathy	2.02	2.84e-3	162/203 (79.8%)	TGFBR2;PDK4;PRKCD;...
Oxidative phosphorylation	2.01	4.55e-3	93/133 (69.92%)	COX5B;NDUFAB1;COX6B1;...
Insulin resistance	1.97	5.69e-3	96/108 (88.89%)	NFKBIA;IRS2;PRKCD;...
Thermogenesis	1.95	1.14e-2	173/232 (74.57%)	ACSL1;RPS6KA2;COX5B;...
Tyrosine metabolism	1.92	1.28e-2	30/36 (83.33%)	MAOA;ADH1B;ADH1C;...
AMPK signaling pathway	1.88	1.52e-2	106/120 (88.33%)	IRS2;PIK3R1;FOXO1;...
Glyoxylate and dicarboxylate metabolism	1.85	2.27e-2	23/30 (76.67%)	GLUL;SHMT1;ACO1;...
PPAR signaling pathway	1.84	2.07e-2	66/74 (89.19%)	ACSL1;LPL;FABP4;...
Citrate cycle (TCA cycle)	1.84	1.90e-2	30/30 (100%)	IDH2;OGDH;PCK2;...
Phenylalanine metabolism	1.83	1.92e-2	14/17 (82.35%)	MAOA;AOC3;GOT1;...
Fatty acid degradation	1.82	1.87e-2	40/43 (93.02%)	ACSL1;ADH1B;ADH1C;...
Insulin signaling pathway	1.79	2.27e-2	121/137 (88.32%)	MKNK2;IRS2;SORBS1;...
Adipocytokine signaling pathway	1.79	2.13e-2	64/69 (92.75%)	NFKBIA;ACSL1;IRS2;...
Nitrogen metabolism	1.79	2.01e-2	16/17 (94.12%)	GLUL;CA2
Drug metabolism	1.78	1.96e-2	78/151 (51.66%)	MAOA;ADH1B;NAT1;...
FoxO signaling pathway	1.76	2.39e-2	118/131 (90.08%)	TGFBR2;GADD45B;IRS2;...
Peroxisome	1.74	2.56e-2	72/82 (87.8%)	ACSL1;SOD2;IDH2;...
Small cell lung cancer	1.73	2.87e-2	90/92 (97.83%)	NFKBIA;GADD45B;PIK3R1;...
Cardiac muscle contraction	1.72	3.26e-2	64/87 (73.56%)	TNNC1;COX5B;ATP1A1;...
Maturity onset diabetes of the young	-1.80	4.83e-2	21/26 (80.77%)	NEUROD1;GCK;MNX1;...
Rheumatoid arthritis	-1.90	4.03e-2	78/93 (83.87%)	IFNG;MMP1;CTSL;...
Viral protein interaction with cytokine and cytokine re...	-1.96	4.03e-2	84/100 (84%)	CCR5;IL20RA;CCR9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼