Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMUY35B)

Drug Name
Progesterone Drug Info
Synonyms
progesterone; 57-83-0; Agolutin; Pregn-4-ene-3,20-dione; Luteohormone; Crinone; 4-Pregnene-3,20-dione; Utrogestan; Syngesterone; Progestin; Luteol; Corpus luteum hormone; Progesterol; Progesteronum; Pregnenedione; Glanducorpin; Prometrium; Corlutin; Cyclogest; Progestron; Gestormone; Progestone; Gestone; Progestasert; Progestronol; Methylpregnone; Hormoflaveine; Syngestrets; Proluton; Progekan; Nalutron; Lutoform; Gynlutin; Gesterol; Fologenon; Corporin; Corlutina; Syntolutan; Prolidon; Membrettes; Lutocyclin; Luteodyn; Lucorteum; Corluvite; LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine
Cross-matching ID
PubChem CID
5994
ChEBI ID
CHEMBL103
CAS Number
CAS 57-83-0
TTD Drug ID
D07BSQ
VARIDT Drug ID
DR00281
INTEDE Drug ID
DR1346
ACDINA Drug ID
D00560

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 1.97 6.22e-3 76/85 (89.41%) F3;SERPINB2;SERPING1;...
Steroid biosynthesis 1.95 3.11e-3 19/20 (95%) DHCR24;MSMO1;LSS;...
Cytokine-cytokine receptor interaction -1.67 3.95e-2 246/295 (83.39%) CSF1;IL19;CD40LG;...
Allograft rejection -1.67 3.93e-2 32/38 (84.21%) HLA-E;HLA-G;CD40LG;...
Ferroptosis -1.68 3.99e-2 36/41 (87.8%) ACSL5;SLC7A11;FTL;...
Folate biosynthesis -1.69 3.69e-2 23/26 (88.46%) QDPR;TPH1;AKR1B10;...
Ribosome -1.69 3.88e-2 113/158 (71.52%) MRPL24;RPS24;MRPL13;...
Metabolism of xenobiotics by cytochrome P450 -1.74 3.00e-2 49/77 (63.64%) ADH6;CYP2A6;CBR1;...
Fructose and mannose metabolism -1.76 2.67e-2 30/33 (90.91%) KHK;GMDS;ALDOB;...
Th1 and Th2 cell differentiation -1.76 2.75e-2 80/92 (86.96%) NFKB1;IL2RA;RELA;...
Fatty acid degradation -1.76 2.84e-2 40/43 (93.02%) ACADS;ACSL5;GCDH;...
Lysosome -1.77 2.74e-2 115/128 (89.84%) GGA2;AGA;CTSO;...
Tryptophan metabolism -1.77 2.95e-2 35/42 (83.33%) GCDH;HADHA;IDO1;...
Kaposi sarcoma-associated herpesvirus infection -1.78 2.48e-2 172/193 (89.12%) UBC;MAPKAPK2;CREB1;...
beta-Alanine metabolism -1.80 2.19e-2 25/30 (83.33%) MLYCD;GAD2;AOC2;...
Oxidative phosphorylation -1.80 2.27e-2 93/133 (69.92%) ATP6V1H;ATP4A;NDUFA4L2;...
Antigen processing and presentation -1.82 1.89e-2 60/78 (76.92%) HSPA1L;CANX;HSP90AB1;...
Autoimmune thyroid disease -1.82 2.13e-2 46/53 (86.79%) HLA-E;HLA-G;CD40LG;...
Galactose metabolism -1.84 1.42e-2 26/31 (83.87%) GLB1;HK1;HKDC1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.85 1.66e-2 62/70 (88.57%) ATP6V1A;PAK1;ATP6V1C1;...
Rheumatoid arthritis -1.86 1.14e-2 78/93 (83.87%) TNFSF11;IL11;IL23A;...
Collecting duct acid secretion -1.90 1.42e-2 22/27 (81.48%) ATP4A;ATP6V1A;ATP6V1C1;...
Glycolysis / Gluconeogenesis -1.94 1.42e-2 56/67 (83.58%) ENO3;ALDOB;PGK1;...
Other glycan degradation -2.00 0.00e+0 13/18 (72.22%) AGA;HEXB;GLB1;...
Viral protein interaction with cytokine and cytokine re... -2.05 0.00e+0 84/100 (84%) CSF1;IL19;ACKR3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H