Details of the Drug Pharmacogenomic Perturbation Atlas

Src kinase inhibitor I Drug Info

Src Kinase Inhibitor I; 179248-59-0; Src I1; Src Inhibitor 1; Src I 1; Src Inhibitor-1; Src-l1; 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine; SKI-1; CHEMBL97771; CHEBI:78332; 6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; 4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-; 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE; -Phenoxyanilino)-6,7-dimethoxyquinazoline; Src-I1; AC1LT1HN; Bionet1_003516; Oprea1_231056; GTPL6042; SCHEMBL1387206; KS-00002WRA; HMS578L18; CTK0E3319; AOB5689; DTXSID50363056

Cross-matching ID

PubChem CID

1474853

ChEBI ID

CHEMBL97771

CAS Number

CAS 179248-59-0

TTD Drug ID

D0U2QT

General Information of Drug (ID: DMUZP9V)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Maturity onset diabetes of the young	2.01	8.70e-3	21/26 (80.77%)	HES1;NKX2-2;PAX6;...
N-Glycan biosynthesis	1.96	8.70e-3	38/50 (76%)	MAN2A1;FUT8;ST6GAL1;...
IL-17 signaling pathway	1.88	2.03e-2	84/94 (89.36%)	CXCL1;NFKBIA;CCL20;...
Legionellosis	1.79	2.83e-2	51/57 (89.47%)	CXCL1;C3;NFKBIA;...
Various types of N-glycan biosynthesis	1.77	2.96e-2	26/39 (66.67%)	MAN2A1;FUT8;B4GALT3;...
Alanine, aspartate and glutamate metabolism	-1.71	2.56e-2	27/37 (72.97%)	ABAT;ASL;ALDH4A1;...
Type I diabetes mellitus	-1.73	2.16e-2	38/43 (88.37%)	HLA-DPA1;HLA-DPB1;CD86;...
Glycine, serine and threonine metabolism	-1.73	2.34e-2	31/40 (77.5%)	PSPH;SHMT1;SARDH;...
Autoimmune thyroid disease	-1.74	2.14e-2	46/53 (86.79%)	HLA-DPA1;HLA-DPB1;CD86;...
Riboflavin metabolism	-1.75	2.02e-2	7/8 (87.5%)	ACP2;FLAD1;ACP1;...
Primary immunodeficiency	-1.79	1.25e-2	33/38 (86.84%)	CIITA;CD4;IL7R;...
Proximal tubule bicarbonate reclamation	-1.79	1.26e-2	21/23 (91.3%)	GLUD1;MDH1;GLUD2;...
Renin-angiotensin system	-1.82	1.12e-2	20/23 (86.96%)	CPA3;ANPEP;PRCP;...
Peroxisome	-1.83	1.31e-2	72/82 (87.8%)	ACOX2;PXMP4;ECI2;...
Allograft rejection	-1.84	1.12e-2	32/38 (84.21%)	HLA-DPA1;HLA-DPB1;CD86;...
Staphylococcus aureus infection	-1.86	1.12e-2	72/95 (75.79%)	CFB;HLA-DOA;FPR3;...
Intestinal immune network for IgA production	-2.09	0.00e+0	38/48 (79.17%)	IL15;HLA-DPA1;ITGA4;...
Mineral absorption	-2.20	0.00e+0	48/60 (80%)	SLC39A4;SLC31A1;SLC34A1;...
Asthma	-2.29	0.00e+0	25/31 (80.65%)	HLA-DPA1;HLA-DPB1;RNASE3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
K-562	CVCL_0004	Homo sapiens	0.01uM - 10uM	24H

Multiple myeloma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
KMS-34	CVCL_1333	Homo sapiens	0.01uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Lymph node

Burkitt lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BJAB	CVCL_5711	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Diffuse large B-cell lymphoma

Mantle cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MINO	CVCL_4965	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Peripheral blood

Acute B-lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NALM-6	CVCL_0092	Homo sapiens	0.01uM - 10uM	24H

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma