Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV04ES)

Drug Name
Rotenone Drug Info
Synonyms
rotenone; 83-79-4; Paraderil; Dactinol; Tubatoxin; (-)-Rotenone; Barbasco; (-)-cis-Rotenone; Derris; Derrin; Cube root; Rotocide; Nicouline; Rotenon; Noxfish; Ronone; Deril; Canex; Liquid Derris; Cube-Pulver; Dri-Kil; Rotessenol; Rotenox; Rotefive; Noxfire; Rotefour; Mexide; Haiari; Cubor; Derris root; Powder and root; Pro-nox fish; Chem-Mite; Cenol garden dust; Curex flea duster; Prenfish; Prentox; Gerane; Synpren; Ro-Ko; Derris (insecticide); Chem fish; Pb-nox; Rotenox 5EC; 5'-beta-Rotenone; Green Cross Warble Powder; Prentox Synpren-Fish; Chem-Fish S
Cross-matching ID
PubChem CID
6758
ChEBI ID
CHEMBL429023
CAS Number
CAS 83-79-4
TTD Drug ID
D0F7CS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.47 0.00e+0 80/88 (90.91%) ITGA6;LAMB1;ITGA5;...
Focal adhesion 2.28 0.00e+0 180/201 (89.55%) ACTN4;ITGA6;LAMB1;...
Mineral absorption 2.28 0.00e+0 48/60 (80%) MT1E;MT1H;MT1F;...
Malaria 2.02 0.00e+0 44/50 (88%) CXCL8;IL1B;THBS1;...
AGE-RAGE signaling pathway in diabetic complications 2.02 0.00e+0 97/100 (97%) CXCL8;SERPINE1;IL1B;...
Hippo signaling pathway 2.00 0.00e+0 120/186 (64.52%) AREG;SERPINE1;SMAD3;...
Rap1 signaling pathway 1.91 4.94e-3 184/210 (87.62%) THBS1;EGFR;PDGFA;...
PI3K-Akt signaling pathway 1.88 4.33e-3 317/354 (89.55%) AREG;ITGA6;LAMB1;...
Regulation of actin cytoskeleton 1.88 3.85e-3 185/218 (84.86%) ACTN4;ITGA6;ITGA5;...
Phospholipase D signaling pathway 1.87 4.61e-3 134/148 (90.54%) CXCL8;EGFR;PDGFA;...
ErbB signaling pathway 1.86 4.20e-3 79/85 (92.94%) AREG;EREG;NCK2;...
Amoebiasis 1.86 3.85e-3 99/102 (97.06%) CXCL8;CXCL1;IL1B;...
IL-17 signaling pathway 1.85 3.55e-3 84/94 (89.36%) CXCL8;CXCL1;IL1B;...
Ras signaling pathway 1.79 1.40e-2 201/232 (86.64%) EGFR;PDGFA;ETS2;...
TGF-beta signaling pathway 1.75 1.85e-2 81/94 (86.17%) THBS1;GREM1;SMAD3;...
Regulation of lipolysis in adipocytes 1.72 3.03e-2 52/55 (94.55%) PTGS2;MGLL;GNAS;...
Progesterone-mediated oocyte maturation 1.70 3.87e-2 75/100 (75%) PLK1;AURKA;CCNA2;...
Allograft rejection -1.81 3.69e-2 32/38 (84.21%) HLA-DRA;TNF;PRF1;...
Antigen processing and presentation -1.87 8.38e-3 60/78 (76.92%) CANX;HSPA1L;HSPA8;...
DNA replication -1.89 1.12e-2 34/36 (94.44%) RFC3;POLE;RPA1;...
Protein processing in endoplasmic reticulum -2.16 0.00e+0 127/171 (74.27%) DNAJC10;SEC31B;CKAP4;...
Steroid biosynthesis -2.30 0.00e+0 19/20 (95%) CYP27B1;FDFT1;LSS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.66uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.05uM - 12uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.66uM 6H
HT-29 CVCL_0320 Homo sapiens 0.05uM - 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.66uM 6H
MDST8 CVCL_1400 Homo sapiens 0.66uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.66uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.66uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.66uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.66uM 6H
SW480 CVCL_0546 Homo sapiens 0.66uM 6H
SW620 CVCL_0547 Homo sapiens 0.66uM 6H
SW948 CVCL_0550 Homo sapiens 0.66uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.66uM 6H
HT115 CVCL_1294 Homo sapiens 0.66uM 6H
RKO CVCL_0504 Homo sapiens 0.66uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.66uM 6H
SNG-M CVCL_1707 Homo sapiens 0.66uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.66uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.66uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.05uM - 40uM 3H, 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 0.125uM - 0.66uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.66uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 0.66uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.66uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.66uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.66uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.66uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.66uM 6H
HCC515 CVCL_5134 Homo sapiens 0.66uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.66uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.66uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.66uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.66uM 6H
OV7 CVCL_1623 Homo sapiens 0.66uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.66uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.66uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.66uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.66uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.66uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.66uM 6H
PL-21 CVCL_2161 Homo sapiens 0.66uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.66uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.05uM - 12uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.66uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.05uM - 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.66uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.66uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.66uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.66uM 6H