Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV19K7)

Drug Name
TRYPTOLINE Drug Info
Synonyms
16502-01-5; Tryptoline; 2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole; Noreleagnine; 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole; 1,2,3,4-Tetrahydro-beta-carboline; Tetrahydro-beta-carboline; THBC; Tetrahydronorharman; UNII-65027TMI0H; 1H,2H,3H,4H,9H-Pyrido[3,4-B]Indole; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-; 2,3,4,9-tetrahydro-1H-beta-carboline; MLS000069483; CHEMBL269236; 65027TMI0H; SMR000059115; Triptoline; Tetrahydronorharmane; Tetrahydro-beta-carboline, 98%; 1,2,3,4-tetrahydrobeta-carboline
Cross-matching ID
PubChem CID
107838
ChEBI ID
CHEMBL269236
CAS Number
CAS 16502-01-5
TTD Drug ID
D03LPH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.35 0.00e+0 110/124 (88.71%) CCNB1;DBF4;CDKN1B;...
DNA replication 2.02 0.00e+0 34/36 (94.44%) PCNA;RFC4;POLE2;...
Proteasome 1.80 3.42e-2 44/46 (95.65%) IFNG;PSMB9;PSMA2;...
Cardiac muscle contraction -1.91 1.06e-2 64/87 (73.56%) MYH6;FXYD2;COX5B;...
Protein export -1.92 1.06e-2 17/23 (73.91%) SRPRB;SEC11A;SEC61B;...
Glyoxylate and dicarboxylate metabolism -1.92 1.59e-2 23/30 (76.67%) CAT;ACO2;GRHPR;...
Protein processing in endoplasmic reticulum -2.06 1.06e-2 127/171 (74.27%) MAP3K5;ERO1A;MBTPS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H