Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV2DY3)

• Drug Name: CARIPORIDE Drug Info
• Synonyms: Cariporide mesylate; UNII-0543W2JFRZ; 159138-81-5; Cariporide mesylate [USAN]; CHEMBL462831; 0543W2JFRZ; Cariporide mesylate (USAN); Cariporide mesilate; N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine; DSSTox_RID_82284; DSSTox_CID_27344; DSSTox_GSID_47344; SCHEMBL221094; DTXSID3047344; AC1L4343; Tox21_300231; NCGC00254230-01; CAS-159138-81-5; D03406; (4-isopropyl-3-methanesulfonyl-benzoyl) guanidine methanesulfonate; Benzamide, N-(aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-, monomethanesulfonate
• Cross-matching ID:
  PubChem CID: 151172
  ChEBI ID: CHEMBL436559
  CAS Number: CAS 159138-80-4
  TTD Drug ID: D0N8QQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Toll-like receptor signaling pathway	2.05	0.00e+0	94/104 (90.38%)	TLR4;SPP1;CD14;...
Ribosome	1.96	0.00e+0	113/158 (71.52%)	RPS5;RPL29;RPL13;...
Glycolysis / Gluconeogenesis	1.91	8.98e-3	56/67 (83.58%)	PGAM1;GPI;TPI1;...
Metabolism of xenobiotics by cytochrome P450	1.90	6.74e-3	49/77 (63.64%)	AKR7A2;GSTP1;UGT2A3;...
Complement and coagulation cascades	1.89	5.39e-3	76/85 (89.41%)	CLU;SERPINA1;TFPI;...
Neutrophil extracellular trap formation	1.89	4.49e-3	101/189 (53.44%)	TLR4;FPR1;CYBB;...
Drug metabolism	1.88	7.70e-3	78/151 (51.66%)	GSTP1;UGT2A3;NME4;...
Oxidative phosphorylation	1.82	1.85e-2	93/133 (69.92%)	NDUFV2;ATP5MC2;ATP5MF;...
Huntington disease	1.78	3.14e-2	233/306 (76.14%)	TGM2;POLR2I;PSMB3;...
Ferroptosis	1.77	3.91e-2	36/41 (87.8%)	CYBB;ACSL5;SAT1;...
Butanoate metabolism	1.75	3.80e-2	23/28 (82.14%)	HMGCS2;BDH2;ECHS1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	1.73	4.15e-2	79/89 (88.76%)	TLR4;PRKCQ;NFKBIE;...
Peroxisome	1.73	3.83e-2	72/82 (87.8%)	SLC27A2;ECI2;PHYH;...
Diabetic cardiomyopathy	1.70	4.91e-2	162/203 (79.8%)	CYBB;PPP1CA;CYBA;...
Non-alcoholic fatty liver disease	1.69	4.85e-2	126/155 (81.29%)	CDC42;NDUFV2;PRKAG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼