Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV2X1B)

Drug Name
Farnesol Drug Info
Synonyms
farnesol; 4602-84-0; Farnesyl alcohol; 3,7,11-trimethyldodeca-2,6,10-trien-1-ol; Spectrum_001282; 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2Z,6Z)-; ACMC-20aplp; ACMC-209ukw; SpecPlus_000549; AC1L1FOK; Spectrum3_001070; Spectrum2_001397; Spectrum4_001221; KBioSS_001762; KBioGR_001682; 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6Z)-; DivK1c_006645; SPBio_001414; GTPL3215; DTXSID3032389; KBio2_006898; KBio1_001589; KBio3_001880; KBio2_004330; CTK1B4647; CTK1D5922; KBio2_001762; CTK0H6624; CTK0E6577; MolPort-006-116-336
Cross-matching ID
PubChem CID
445070
ChEBI ID
CHEMBL25308
CAS Number
CAS 4602-84-0
TTD Drug ID
D0M0CF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Drug metabolism -1.71 3.25e-2 78/151 (51.66%) ADH1C;CYP3A4;GMPS;...
Metabolism of xenobiotics by cytochrome P450 -1.71 3.57e-2 49/77 (63.64%) CYP1A1;CYP2D6;AKR7A3;...
Tryptophan metabolism -1.72 3.61e-2 35/42 (83.33%) ALDH7A1;HADHA;TDO2;...
Viral protein interaction with cytokine and cytokine re... -1.72 4.06e-2 84/100 (84%) CXCL13;TNFRSF10D;CXCR4;...
Steroid hormone biosynthesis -1.74 4.33e-2 43/61 (70.49%) UGT2B4;SRD5A1;UGT2B15;...
Sphingolipid metabolism -1.74 4.51e-2 32/49 (65.31%) GAL3ST1;NEU1;PLPP2;...
Renin-angiotensin system -1.78 2.60e-2 20/23 (86.96%) AGT;ANPEP;CPA3;...
Mineral absorption -1.79 2.98e-2 48/60 (80%) FTL;SLC5A1;SLC31A1;...
Lysosome -1.82 2.17e-2 115/128 (89.84%) PPT1;FUCA1;CTSZ;...
Ferroptosis -2.01 5.41e-3 36/41 (87.8%) GPX4;MAP1LC3B;ACSL3;...
IL-17 signaling pathway -2.02 1.08e-2 84/94 (89.36%) TRAF5;TRAF3IP2;CCL17;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H