Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV2XUM)

Drug Name
BRL50481 Drug Info
Synonyms BRL-50481; BRL 50481
Cross-matching ID
PubChem CID
2921148
ChEBI ID
CHEMBL484928
CAS Number
CAS 433695-36-4
TTD Drug ID
D00MBG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.97 0.00e+0 34/36 (94.44%) POLE2;MCM5;RFC2;...
Peroxisome 1.85 2.26e-2 72/82 (87.8%) ACAA1;SOD2;PIPOX;...
Fanconi anemia pathway 1.83 1.94e-2 36/54 (66.67%) MLH1;CENPX;BLM;...
Complement and coagulation cascades 1.79 2.91e-2 76/85 (89.41%) SERPINA1;A2M;CFI;...
Systemic lupus erythematosus 1.78 2.84e-2 45/135 (33.33%) C7;C1QA;C1QB;...
Histidine metabolism 1.74 3.98e-2 16/22 (72.73%) HNMT;MAOB;ALDH7A1;...
Valine, leucine and isoleucine degradation 1.73 3.69e-2 42/48 (87.5%) ACAA1;ACAT2;ABAT;...
Mismatch repair 1.70 4.84e-2 22/23 (95.65%) MLH1;RFC2;MSH6;...
Mitophagy -1.95 2.75e-2 56/68 (82.35%) TBC1D15;JUN;HIF1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H