Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV3UN4)

Drug Name
JTC-801 Drug Info
Synonyms
UNII-BXU45ZH6LI; BXU45ZH6LI; 244218-93-7; CHEMBL140979; N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide; N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide; JTC-801 free base; AC1NSKGH; SCHEMBL4916443; GTPL1692; CHEBI:92314; MolPort-021-804-962; ZINC602902; BCPP000197; BDBM50094634; N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]Benzamide; Benzamide, N-(4-amino-2-methyl-6-quinolinyl)-2-((4-ethylphenoxy)methyl)-; SB19531; BCP9000806; NCGC00161418-01; NCGC00161418-02
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
5311339
ChEBI ID
CHEMBL531742
CAS Number
CAS 244218-51-7
TTD Drug ID
D08SNL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hepatitis C 1.99 0.00e+0 139/157 (88.54%) RSAD2;CLDN4;IFIT1;...
Steroid biosynthesis 1.96 0.00e+0 19/20 (95%) SQLE;MSMO1;DHCR24;...
Measles 1.95 0.00e+0 133/139 (95.68%) OAS3;HSPA1A;HSPA8;...
RIG-I-like receptor signaling pathway 1.94 0.00e+0 64/70 (91.43%) ISG15;CASP10;IFIH1;...
Prostate cancer 1.90 0.00e+0 93/97 (95.88%) SPINT1;TGFA;MMP3;...
Estrogen signaling pathway 1.84 3.50e-3 119/137 (86.86%) KRT23;KRT14;HSPA1A;...
TNF signaling pathway 1.77 1.80e-2 103/112 (91.96%) CXCL2;EDN1;CASP10;...
IL-17 signaling pathway 1.75 2.36e-2 84/94 (89.36%) CXCL2;S100A7;MMP3;...
Osteoclast differentiation 1.72 3.73e-2 117/127 (92.13%) SIRPA;RELB;IFNGR1;...
Fatty acid elongation -1.71 1.24e-2 19/27 (70.37%) HADHA;ECHS1;PPT1;...
Thermogenesis -1.71 1.25e-2 173/232 (74.57%) NDUFS2;NDUFB6;MAPK14;...
Systemic lupus erythematosus -1.71 1.23e-2 45/135 (33.33%) C6;HLA-DRA;C8B;...
Arachidonic acid metabolism -1.73 1.13e-2 48/61 (78.69%) ALOX15;CYP2C9;CYP2C8;...
Pentose and glucuronate interconversions -1.74 1.03e-2 17/34 (50%) AKR1A1;UGT2B15;CRYL1;...
Proximal tubule bicarbonate reclamation -1.75 9.96e-3 21/23 (91.3%) MDH1;ATP1B2;ATP1A1;...
Peroxisome -1.75 9.97e-3 72/82 (87.8%) ACOT8;PEX11B;MLYCD;...
Lysine degradation -1.77 8.33e-3 51/63 (80.95%) EHHADH;HADHA;SUV39H1;...
Renin-angiotensin system -1.78 8.27e-3 20/23 (86.96%) CPA3;ATP6AP2;ENPEP;...
African trypanosomiasis -1.79 7.75e-3 32/37 (86.49%) SELE;KNG1;FAS;...
Diabetic cardiomyopathy -1.80 7.18e-3 162/203 (79.8%) NDUFA8;COX7A2L;PDHA1;...
DNA replication -1.81 6.55e-3 34/36 (94.44%) MCM5;POLA1;POLA2;...
Glutathione metabolism -1.83 6.38e-3 43/57 (75.44%) G6PD;GCLC;GSR;...
Propanoate metabolism -1.84 6.19e-3 30/34 (88.24%) SUCLG2;SUCLG1;ECHDC1;...
Porphyrin and chlorophyll metabolism -1.86 4.79e-3 23/43 (53.49%) COX15;HMBS;UGT2B15;...
Pyruvate metabolism -1.87 4.47e-3 41/47 (87.23%) PKLR;ACACB;ADH1A;...
beta-Alanine metabolism -1.88 4.10e-3 25/30 (83.33%) AOC3;ALDH3B1;ALDH3A1;...
Citrate cycle (TCA cycle) -1.92 3.68e-3 30/30 (100%) SUCLG2;SUCLG1;SDHB;...
Complement and coagulation cascades -1.93 3.19e-3 76/85 (89.41%) C8A;SERPIND1;SERPINF2;...
Glycine, serine and threonine metabolism -1.95 2.61e-3 31/40 (77.5%) AGXT;SHMT1;GNMT;...
Tyrosine metabolism -1.98 1.91e-3 30/36 (83.33%) AOC3;ALDH3B1;FAH;...
Glyoxylate and dicarboxylate metabolism -2.00 1.06e-3 23/30 (76.67%) AGXT;SHMT1;CAT;...
Oxidative phosphorylation -2.03 0.00e+0 93/133 (69.92%) ATP5F1A;NDUFS7;ATP5PD;...
Mineral absorption -2.10 0.00e+0 48/60 (80%) ATP1B2;HEPH;ATP1A1;...
Drug metabolism -2.19 0.00e+0 78/151 (51.66%) FMO4;UGT2B15;ALDH3B1;...
Valine, leucine and isoleucine degradation -2.22 0.00e+0 42/48 (87.5%) HSD17B10;ACAA1;PCCA;...
Fatty acid degradation -2.28 0.00e+0 40/43 (93.02%) ACAA1;ACSBG1;EHHADH;...
Tryptophan metabolism -2.33 0.00e+0 35/42 (83.33%) EHHADH;HADHA;GCDH;...
Retinol metabolism -2.37 0.00e+0 41/68 (60.29%) HSD17B6;PNPLA4;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450 -2.48 0.00e+0 49/77 (63.64%) UGT2B15;ALDH3B1;GSTP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 3.33uM 24H