Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV632P)

Drug Name
CEP-37440 Drug Info
Synonyms Dual ALK/FAK inhibitor (cancer), Cephalon; Dual anaplastic lymphoma kinase/focal adhesion kinase inhibitor (cancer),Cephalon
Cross-matching ID
PubChem CID
71721648
ChEBI ID
CHEMBL3951811
CAS Number
CAS 1391712-60-9
TTD Drug ID
D0N6NM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 1.91 1.79e-2 66/74 (89.19%) SCD;HMGCS1;PLIN2;...
Histidine metabolism 1.86 2.69e-2 16/22 (72.73%) HNMT;HAL;ALDH9A1;...
Ascorbate and aldarate metabolism 1.79 3.59e-2 15/30 (50%) GUSB;AKR1A1;UGT2B4;...
Cellular senescence -1.63 3.75e-2 139/156 (89.1%) RAD1;HIPK3;NFATC1;...
Viral myocarditis -1.65 3.13e-2 53/60 (88.33%) RAC3;HLA-DRB1;CD40LG;...
Alzheimer disease -1.66 2.91e-2 279/369 (75.61%) ATP5F1B;ATP5F1C;PSMC5;...
Arginine and proline metabolism -1.67 2.78e-2 39/50 (78%) SMOX;ALDH18A1;CKM;...
Pathways of neurodegeneration -1.68 2.70e-2 354/475 (74.53%) ATP5F1B;ATP5F1C;PSMC5;...
p53 signaling pathway -1.68 2.55e-2 63/73 (86.3%) CASP8;GTSE1;CHEK1;...
RNA transport -1.73 1.56e-2 128/186 (68.82%) MAGOH;EIF3B;RANGAP1;...
Progesterone-mediated oocyte maturation -1.74 1.59e-2 75/100 (75%) HSP90AB1;CDC25C;PKMYT1;...
Type I diabetes mellitus -1.74 1.69e-2 38/43 (88.37%) HLA-DRB1;HLA-DOA;IL12A;...
Nucleotide excision repair -1.80 9.75e-3 40/47 (85.11%) LIG1;ERCC3;RAD23A;...
Folate biosynthesis -1.83 7.23e-3 23/26 (88.46%) CBR1;FPGS;QDPR;...
Oocyte meiosis -1.91 2.60e-3 90/129 (69.77%) CDC25C;PKMYT1;FBXO5;...
Epstein-Barr virus infection -1.92 2.81e-3 189/202 (93.56%) E2F1;HLA-C;HLA-DRA;...
DNA replication -1.93 3.07e-3 34/36 (94.44%) POLD1;POLE;RNASEH2B;...
Graft-versus-host disease -1.94 2.25e-3 32/42 (76.19%) HLA-DRB1;HLA-DOA;HLA-C;...
Ribosome biogenesis in eukaryotes -1.97 1.25e-3 52/108 (48.15%) GNL3;NOP56;TCOF1;...
Amyotrophic lateral sclerosis -1.99 1.41e-3 267/364 (73.35%) PSMA1;GPX1;NUP58;...
Huntington disease -1.99 1.61e-3 233/306 (76.14%) GPX7;TBP;ATP5F1B;...
RNA polymerase -2.00 1.87e-3 23/31 (74.19%) POLR3G;POLR3C;POLR2E;...
Spinocerebellar ataxia -2.02 2.25e-3 128/143 (89.51%) NOP56;MAPK9;PIK3R3;...
Prion disease -2.12 0.00e+0 209/273 (76.56%) ATP5F1B;ATP5F1C;PSMC5;...
Cell cycle -2.13 0.00e+0 110/124 (88.71%) CHEK1;MCM4;CCND3;...
Parkinson disease -2.17 0.00e+0 176/249 (70.68%) ATP5F1B;ATP5F1C;PSMC5;...
Proteasome -2.64 0.00e+0 44/46 (95.65%) PSMD9;PSMA1;PSMC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H