Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMV74ZH)

Drug Name
Pizotyline Drug Info
Synonyms
Pizotifen; PIZOTYLINE; 15574-96-6; Sandomigran; Litec; Sandomygran; Pizotifenum; Pizotifeno; Polomigran; Pizotifene; BC-105; BC 105; Pizotyline [USAN]; Pizotifan; Pizotifene [INN-French]; Pizotifenum [INN-Latin]; Pizotifeno [INN-Spanish]; UNII-0BY8440V3N; EINECS 239-632-9; BRN 0753534; C19H21NS; CHEBI:50212; FIADGNVRKBPQEU-UHFFFAOYSA-N; Pizotifen (INN); Pizotifen [INN]; 0BY8440V3N; Pizotyline (USAN); 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
Cross-matching ID
PubChem CID
27400
ChEBI ID
CHEMBL294951
CAS Number
CAS 15574-96-6
TTD Drug ID
D06XZR
INTEDE Drug ID
DR1308

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.52 0.00e+0 19/20 (95%) MSMO1;SQLE;NSDHL;...
Lysosome 2.03 4.89e-3 115/128 (89.84%) NPC2;HEXB;LIPA;...
Terpenoid backbone biosynthesis 1.86 1.63e-2 18/22 (81.82%) IDI1;HMGCS1;ACAT2;...
Cytosolic DNA-sensing pathway 1.82 1.47e-2 52/63 (82.54%) CCL5;CXCL10;IKBKE;...
Histidine metabolism -1.72 4.23e-2 16/22 (72.73%) ALDH7A1;MAOA;MAOB;...
Diabetic cardiomyopathy -1.75 3.92e-2 162/203 (79.8%) AKT2;NDUFB6;COL1A1;...
Valine, leucine and isoleucine degradation -1.77 3.88e-2 42/48 (87.5%) ALDH7A1;PCCA;BCKDHA;...
Citrate cycle (TCA cycle) -1.81 2.81e-2 30/30 (100%) PDHA1;DLST;SDHB;...
Oxidative phosphorylation -1.84 2.73e-2 93/133 (69.92%) ATP6V0A1;NDUFA8;NDUFB6;...
Thermogenesis -1.93 1.53e-2 173/232 (74.57%) NPPA;NDUFA8;SMARCD3;...
Proximal tubule bicarbonate reclamation -2.03 1.02e-2 21/23 (91.3%) SLC25A10;ATP1B2;CA4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H