Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVC90W)

Drug Name
Oglemilast Drug Info
Synonyms GRC-3886; Oglemilast (oral, COPD/asthma), Glenmark
Cross-matching ID
PubChem CID
11387409
ChEBI ID
CHEMBL4297520
CAS Number
CAS 778576-62-8
TTD Drug ID
D0L8KJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral carcinogenesis -1.62 4.74e-2 149/203 (73.4%) BAK1;NFKBIA;MAPKAPK2;...
Lysosome -1.63 4.47e-2 115/128 (89.84%) ENTPD4;DNASE2;NPC1;...
ErbB signaling pathway -1.64 4.33e-2 79/85 (92.94%) AKT1;ERBB4;PLCG1;...
Cell adhesion molecules -1.64 4.13e-2 118/148 (79.73%) NCAM2;HLA-DQB1;CD86;...
Retrograde endocannabinoid signaling -1.67 3.06e-2 118/148 (79.73%) GNG4;GABRA2;NDUFB2;...
Chagas disease -1.67 3.08e-2 93/102 (91.18%) GNAI1;RELA;CHUK;...
Staphylococcus aureus infection -1.67 3.17e-2 72/95 (75.79%) HLA-DQB1;KRT33A;KRT36;...
Vibrio cholerae infection -1.68 3.07e-2 44/50 (88%) PRKACB;TJP1;ADCY3;...
Synaptic vesicle cycle -1.69 2.40e-2 63/78 (80.77%) DNM2;SLC6A11;SYT1;...
Kaposi sarcoma-associated herpesvirus infection -1.71 2.39e-2 172/193 (89.12%) BAK1;NFKBIA;TNFRSF1A;...
Apoptosis -1.71 2.46e-2 126/168 (75%) TRADD;PIDD1;RELA;...
Sulfur metabolism -1.73 2.12e-2 9/10 (90%) SELENBP1;ETHE1
Cytokine-cytokine receptor interaction -1.77 1.22e-2 246/295 (83.39%) IL24;ACVR1B;TNFRSF25;...
Natural killer cell mediated cytotoxicity -1.78 1.21e-2 99/131 (75.57%) FYN;SH3BP2;GZMB;...
NF-kappa B signaling pathway -1.80 1.10e-2 90/104 (86.54%) TRAF6;BCL10;BLNK;...
Antigen processing and presentation -1.80 1.20e-2 60/78 (76.92%) HLA-DQB1;HLA-DPB1;CALR;...
Chemokine signaling pathway -1.80 1.31e-2 163/192 (84.9%) GNG3;GNB5;AKT1;...
Legionellosis -1.81 1.17e-2 51/57 (89.47%) NFKBIA;TLR2;NFKB2;...
Mineral absorption -1.81 1.16e-2 48/60 (80%) ATP1B2;FTH1;HMOX2;...
NOD-like receptor signaling pathway -1.82 1.31e-2 145/181 (80.11%) BCL2;ATG16L1;VDAC1;...
Pertussis -1.83 1.49e-2 64/76 (84.21%) IRAK1;TLR4;C4BPA;...
Graft-versus-host disease -2.00 2.18e-3 32/42 (76.19%) GZMB;HLA-DQB1;CD86;...
Viral protein interaction with cytokine and cytokine re... -2.04 2.61e-3 84/100 (84%) CCL21;CX3CL1;CCL2;...
Epithelial cell signaling in Helicobacter pylori infect... -2.07 3.26e-3 62/70 (88.57%) NFKBIA;CSK;CASP3;...
TNF signaling pathway -2.13 4.35e-3 103/112 (91.96%) NFKBIA;TNFRSF1A;LIF;...
IL-17 signaling pathway -2.14 6.53e-3 84/94 (89.36%) NFKBIA;TRAF5;CASP3;...
Rheumatoid arthritis -2.31 0.00e+0 78/93 (83.87%) ATP6V1A;LTB;CCL2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H