Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVI9DM)

Drug Name
ETIOCHOLANOLONE Drug Info
Synonyms
etiocholanolone; 5-Isoandrosterone; 53-42-9; Etiocholan-3alpha-ol-17-one; Aetiocholanolone; 3alpha-Etiocholanolone; 5beta-Androsterone; 3alpha-Hydroxy-5beta-androstan-17-one; 5b-androsterone; Androsterone, (5beta)-; UNII-97CGB1M48I; alpha-Etiocholanolone; 5.beta.-Androsterone; 5beta-Androstan-3alpha-ol-17-one; 3.alpha.-Etiocholanolone; NSC 50908; Androsterone, (5.beta.)-; CHEMBL85799; 97CGB1M48I; 3alpha-Hydroxyetiocholan-17-one; CHEBI:28195; Etiocholan-3.alpha.-ol-17-one; 3a-Hydroxy-5b-androstan-17-one
Cross-matching ID
PubChem CID
5880
ChEBI ID
CHEMBL85799
CAS Number
CAS 53-42-9
TTD Drug ID
D09MWG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Sphingolipid signaling pathway -1.61 4.37e-2 106/119 (89.08%) NSMAF;ROCK1;PIK3R3;...
Fc gamma R-mediated phagocytosis -1.64 4.37e-2 79/97 (81.44%) ASAP1;FCGR2B;AKT2;...
AMPK signaling pathway -1.66 3.58e-2 106/120 (88.33%) GYS2;ADIPOR1;AKT2;...
Valine, leucine and isoleucine degradation -1.67 3.42e-2 42/48 (87.5%) ACADM;ALDH1B1;EHHADH;...
Synthesis and degradation of ketone bodies -1.68 3.24e-2 9/10 (90%) OXCT1;HMGCS1;ACAT1;...
Leukocyte transendothelial migration -1.68 3.32e-2 90/114 (78.95%) PTK2B;ROCK1;PIK3R3;...
Th1 and Th2 cell differentiation -1.71 2.62e-2 80/92 (86.96%) PPP3CB;CD3G;STAT6;...
Alanine, aspartate and glutamate metabolism -1.72 2.44e-2 27/37 (72.97%) CAD;ASNS;CPS1;...
Vitamin digestion and absorption -1.73 2.07e-2 17/24 (70.83%) SLC19A3;BTD;CUBN;...
Herpes simplex virus 1 infection -1.73 2.16e-2 165/498 (33.13%) BAX;IFNG;AKT2;...
Viral myocarditis -1.75 2.07e-2 53/60 (88.33%) HLA-B;RAC2;CASP3;...
Fatty acid degradation -1.76 1.69e-2 40/43 (93.02%) ADH7;ACADS;ALDH2;...
Phagosome -1.77 1.71e-2 118/152 (77.63%) TAP2;RAB5A;MPO;...
Autoimmune thyroid disease -1.77 1.73e-2 46/53 (86.79%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Glyoxylate and dicarboxylate metabolism -1.78 1.50e-2 23/30 (76.67%) HAO1;CAT;ACO1;...
Proximal tubule bicarbonate reclamation -1.81 9.80e-3 21/23 (91.3%) ATP1B2;GLUD1;SLC25A10;...
Biosynthesis of unsaturated fatty acids -1.82 8.59e-3 21/27 (77.78%) SCP2;ACAA1;FADS2;...
Intestinal immune network for IgA production -1.82 8.23e-3 38/48 (79.17%) CXCR4;CD40;HLA-DRB1;...
Fructose and mannose metabolism -1.83 8.91e-3 30/33 (90.91%) KHK;FBP1;SORD;...
Necroptosis -1.84 9.72e-3 113/159 (71.07%) HSP90AA1;STAT6;TLR3;...
Glycolysis / Gluconeogenesis -1.85 9.36e-3 56/67 (83.58%) GPI;ALDH2;PGK2;...
Allograft rejection -1.88 1.04e-2 32/38 (84.21%) CD40;HLA-DRB1;HLA-DPB1;...
PPAR signaling pathway -1.89 8.36e-3 66/74 (89.19%) ACADM;ACSBG2;EHHADH;...
Citrate cycle (TCA cycle) -1.89 7.64e-3 30/30 (100%) ACLY;OGDHL;MDH2;...
Natural killer cell mediated cytotoxicity -1.94 2.23e-3 99/131 (75.57%) PTK2B;PIK3R3;PPP3CB;...
Inflammatory bowel disease -1.95 2.67e-3 58/65 (89.23%) STAT6;IL18RAP;TLR2;...
Graft-versus-host disease -1.98 3.34e-3 32/42 (76.19%) HLA-DRB1;HLA-DPB1;HLA-DOB;...
Asthma -2.00 0.00e+0 25/31 (80.65%) FCER1G;RNASE3;CD40;...
Rheumatoid arthritis -2.05 0.00e+0 78/93 (83.87%) IL23A;CXCL3;LTB;...
Leishmaniasis -2.06 0.00e+0 67/77 (87.01%) ELK1;JAK2;TLR2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H