Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVIRN3)

• Drug Name: N-DESMETHYLCLOZAPINE Drug Info
• Cross-matching ID:
  PubChem CID: 135409468
  ChEBI ID: CHEMBL845
  CAS Number: CAS 6104-71-8
  TTD Drug ID: D0K4HW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.47	0.00e+0	19/20 (95%)	MSMO1;SQLE;DHCR24;...
Biosynthesis of unsaturated fatty acids	2.10	0.00e+0	21/27 (77.78%)	SCD;FADS1;FADS2;...
PPAR signaling pathway	2.07	0.00e+0	66/74 (89.19%)	SCD;HMGCS1;LPL;...
Terpenoid backbone biosynthesis	1.99	0.00e+0	18/22 (81.82%)	HMGCS1;FDPS;IDI1;...
Amino sugar and nucleotide sugar metabolism	1.91	1.58e-3	38/48 (79.17%)	CYB5R2;AMDHD2;HEXA;...
Fatty acid elongation	1.89	2.63e-3	19/27 (70.37%)	ELOVL4;ELOVL6;TECR;...
Cholesterol metabolism	1.74	4.28e-2	44/50 (88%)	LPL;STAR;LDLR;...
Phototransduction	1.72	4.24e-2	21/29 (72.41%)	CALML5;CALML3
Mucin type O-glycan biosynthesis	1.71	4.12e-2	20/36 (55.56%)	GALNT6;GALNT12;GALNT7;...
Protein digestion and absorption	1.68	4.49e-2	78/103 (75.73%)	COL9A3;COL9A2;COL1A2;...
ABC transporters	1.67	4.66e-2	37/45 (82.22%)	ABCB6;ABCA5;ABCA3;...
Salivary secretion	1.67	4.40e-2	76/93 (81.72%)	GNAS;CALML5;CST1;...
Amoebiasis	-1.71	4.31e-2	99/102 (97.06%)	RELA;LAMC2;C8G;...
Legionellosis	-1.72	4.69e-2	51/57 (89.47%)	EEF1A2;HSPD1;RELA;...
NF-kappa B signaling pathway	-1.75	4.29e-2	90/104 (86.54%)	EDA2R;PLCG2;RELB;...
Malaria	-1.76	3.75e-2	44/50 (88%)	ICAM1;CD40;TLR2;...
Chronic myeloid leukemia	-1.78	4.01e-2	72/76 (94.74%)	AKT3;CBL;SMAD4;...
ErbB signaling pathway	-1.80	3.75e-2	79/85 (92.94%)	RAF1;ABL1;MAPK10;...
Bladder cancer	-1.83	4.17e-2	40/41 (97.56%)	TP53;VEGFA;MMP9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼