General Information of Drug (ID: DMVJNFI)

Drug Name
Spermidine Drug Info
Synonyms
Spermidin; UNII-U87FK77H25; BRN 1698591; AI3-26636; EINECS 204-689-0; CHEMBL19612; CHEBI:16610; ATHGHQPFGPMSJY-UHFFFAOYSA-N; U87FK77H25; MFCD00008229; Spermidine hydrochloride; NSC528399; 1pot; Aminopropylbutandiamine; N-(4-Aminobutyl)-1,3-diaminopropane; Spectrum_000005; Tocris-0959; ACMC-20ajn3; AC1L1AQB; Spectrum2_000874; Spectrum3_000977; Spectrum4_001101; Spectrum5_001561; Lopac-S-2501; Biomol-NT_000212; bmse000116; bmse000951; bmse000955; Spermidine 0.1 M solution; Lopac0_001047; SCHEMBL15618; BSPBio_002613; KBioGR_001542; KBioSS_000345; 4-04-00-01300 (Beilstein Handbook Reference); DivK1c_001007; SPBio_000947; Spermidine, > =99% (GC); Spermidine, analytical standard; BPBio1_001276; GTPL2390; DTXSID4036645; CTK3J1693; KBio1_001007; KBio2_000345; KBio2_002913; KBio2_005481; KBio3_001833; MolPort-001-761-230; NINDS_001007; HY-B1776; ZINC1532612; BDBM50009353; PA(34); N-(3-Aminopropyl)-4-aminobutylamine; AKOS006222987; CCG-205124; DB03566; MCULE-8096530192; RTR-003757; SDCCGMLS-0066822.P001; IDI1_001007; NCGC00015937-01; NCGC00015937-02; NCGC00015937-03; NCGC00015937-04; NCGC00015937-05; NCGC00024903-01; NCGC00024903-02; NCGC00024903-03; AJ-26792; AN-22947; LS-45643; M923; NCI60_004294; SC-69371; DB-026892; TR-003757; CS-0013804; FT-0629162; ST24048721; ST45025991; C00315; 124S209; SR0
Cross-matching ID
PubChem CID
1102
ChEBI ID
CHEMBL19612
CAS Number
CAS 124-20-9
TTD Drug ID
D08BXT
VARIDT Drug ID
DR01250
INTEDE Drug ID
DR1504

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 1.81 8.76e-2 101/150 (67.33%) SNRPG;SRSF6;SNRPD1;...
DNA replication 1.70 1.23e-1 34/36 (94.44%) PCNA;RFC5;MCM7;...
Other types of O-glycan biosynthesis 1.64 1.55e-1 29/47 (61.7%) GALNT6;GALNT1;POFUT1;...
Mismatch repair 1.61 1.56e-1 22/23 (95.65%) PCNA;RFC5;RFC4;...
Sulfur relay system 1.57 1.74e-1 5/8 (62.5%) NFS1;TST
Homologous recombination 1.52 2.27e-1 35/41 (85.37%) RBBP8;MRE11;BRCA1;...
Cysteine and methionine metabolism 1.49 2.48e-1 43/50 (86%) AHCY;BHMT2;MAT2A;...
Protein export 1.44 2.77e-1 17/23 (73.91%) SEC61G;SPCS3;SRPRB;...
Retinol metabolism 1.43 2.79e-1 41/68 (60.29%) ALDH1A3;CYP1A1;UGT2B4;...
Mucin type O-glycan biosynthesis 1.39 3.17e-1 20/36 (55.56%) GALNT6;GALNT1;B4GALT5;...
Nucleotide excision repair 1.39 2.98e-1 40/47 (85.11%) PCNA;RFC5;MNAT1;...
Proteasome 1.38 2.89e-1 44/46 (95.65%) PSMB6;PSMD13;PSME4;...
Ribosome biogenesis in eukaryotes 1.37 2.70e-1 52/108 (48.15%) GNL3;NAT10;DKC1;...
Primary immunodeficiency 1.30 4.29e-1 33/38 (86.84%) ADA;DCLRE1C;LCK;...
Cell cycle 1.30 4.02e-1 110/124 (88.71%) PCNA;CDC20;MCM7;...
Porphyrin and chlorophyll metabolism 1.25 5.23e-1 23/43 (53.49%) PPOX;UGT2B4;ALAS2;...
Base excision repair 1.23 5.55e-1 29/33 (87.88%) PCNA;TDG;HMGB1;...
Malaria 1.22 5.43e-1 44/50 (88%) GYPA;THBS4;THBS1;...
Propanoate metabolism 1.17 6.86e-1 30/34 (88.24%) HIBCH;EHHADH;ACAT1;...
Synthesis and degradation of ketone bodies 1.17 6.61e-1 9/10 (90%) BDH2;ACAT1
Cardiac muscle contraction 1.14 7.59e-1 64/87 (73.56%) TPM4;COX7A1;CACNB2;...
TGF-beta signaling pathway 1.14 7.29e-1 81/94 (86.17%) LTBP1;SMURF2;HAMP;...
Staphylococcus aureus infection 1.12 7.64e-1 72/95 (75.79%) KRT19;DEFA5;DEFA6;...
Butanoate metabolism 1.11 7.78e-1 23/28 (82.14%) BDH2;EHHADH;ACAT1;...
Thiamine metabolism 1.09 8.20e-1 12/15 (80%) NFS1;ALPG;ALPL;...
Steroid hormone biosynthesis 1.08 8.09e-1 43/61 (70.49%) COMT;AKR1C4;CYP1A1;...
Systemic lupus erythematosus 1.06 8.09e-1 45/135 (33.33%) SNRPD1;SNRPB;C9;...
Starch and sucrose metabolism 1.05 8.15e-1 25/36 (69.44%) MGAM;GYG1;GYS2
Non-homologous end-joining 1.04 8.20e-1 11/13 (84.62%) DCLRE1C;MRE11
Natural killer cell mediated cytotoxicity 1.02 8.24e-1 99/131 (75.57%) LCK;BID;PIK3R1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.37 3.87e-1 49/53 (92.45%) CLTB;FXYD2;ATP2B3;...
Ferroptosis -1.38 3.79e-1 36/41 (87.8%) PCBP2;SLC39A8;ATG5;...
Circadian entrainment -1.38 3.81e-1 85/97 (87.63%) PER3;CAMK2B;GNG3;...
Melanogenesis -1.38 3.91e-1 74/101 (73.27%) CAMK2B;CREB3L1;FZD1;...
Long-term potentiation -1.40 3.77e-1 61/67 (91.04%) CREBBP;RPS6KA1;PPP1CA;...
Fluid shear stress and atherosclerosis -1.41 3.81e-1 123/139 (88.49%) TRPV4;BMPR1B;CTNNB1;...
Glucagon signaling pathway -1.42 3.58e-1 89/107 (83.18%) PHKG1;PPP4R3A;LDHB;...
Choline metabolism in cancer -1.42 3.59e-1 84/98 (85.71%) SP1;DGKA;JUN;...
Cholinergic synapse -1.43 3.68e-1 99/113 (87.61%) CAMK2B;CREB3L1;GNG3;...
ECM-receptor interaction -1.43 3.68e-1 80/88 (90.91%) ITGB1;LAMC3;CD36;...
Salivary secretion -1.44 3.81e-1 76/93 (81.72%) FXYD2;ATP2B3;GUCY1A1;...
Prostate cancer -1.44 3.87e-1 93/97 (95.88%) CTNNB1;IKBKB;IKBKG;...
Glycosaminoglycan degradation -1.45 3.82e-1 19/19 (100%) SGSH;HYAL1;GUSB;...
Growth hormone synthesis, secretion and action -1.46 3.76e-1 108/119 (90.76%) CREB3L1;ITPR1;MAPK14;...
Bacterial invasion of epithelial cells -1.47 3.65e-1 59/77 (76.62%) ELMO1;CTNNB1;CTTN;...
Phagosome -1.47 3.70e-1 118/152 (77.63%) RAB5B;ATP6V1A;CD14;...
Cholesterol metabolism -1.48 3.69e-1 44/50 (88%) ANGPTL8;CD36;VDAC1;...
Cushing syndrome -1.50 3.34e-1 125/155 (80.65%) CAMK2B;CREB3L1;CDKN2C;...
Ether lipid metabolism -1.50 3.50e-1 32/49 (65.31%) PLD3;PLA2G4C;PLA2G10;...
Nitrogen metabolism -1.51 3.45e-1 16/17 (94.12%) CA6;GLUD1;CA7;...
Aldosterone synthesis and secretion -1.52 3.66e-1 85/98 (86.73%) CAMK2B;CREB3L1;ITPR1;...
Thyroid hormone synthesis -1.55 3.13e-1 66/75 (88%) GPX2;CREB3L1;ITPR1;...
Cortisol synthesis and secretion -1.56 3.21e-1 58/65 (89.23%) CREB3L1;ITPR1;AGTR1;...
Pertussis -1.57 3.24e-1 64/76 (84.21%) C4BPB;MAPK10;CD14;...
Insulin resistance -1.59 3.20e-1 96/108 (88.89%) RPS6KA1;OGA;PPP1CA;...
GnRH signaling pathway -1.59 3.62e-1 80/93 (86.02%) CAMK2B;ITPR1;EGR1;...
Sphingolipid metabolism -1.61 3.63e-1 32/49 (65.31%) NEU1;SPHK1;SMPD1;...
Lysosome -1.68 3.56e-1 115/128 (89.84%) CTSO;LIPA;ASAH1;...
Protein digestion and absorption -1.74 3.30e-1 78/103 (75.73%) CELA3A;KCNN4;KCNK5;...
Fatty acid elongation -1.83 3.30e-1 19/27 (70.37%) ACOT7;ACAA2;ELOVL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H