Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVJS2K)

• Drug Name: Monobenzone Drug Info
• Synonyms: Agerite; Alba; Benoquin; Benzoquin; Carmifal; Depigman; Dermochinona; Leucodinine; Monobenzon; Monobenzona; Monobenzonum; PBP; Pigmex; Superlite; Agerite alba; Benzyl hydroquinone; Hydrochinon monobenzylether; Hydrochinon monobenzylether [Czech]; Hydroquinone benzyl ether; Hydroquinone monobenzyl ether; ICN brand of monobenzone; Monobenzone [INN]; Monobenzyl Ether of Hydroquinone; Monobenzyl ether hydroquinone; Monobenzyl hydroquinone; Alba-Dome; Benoquin (TN); Benoquin, Monobenzone; Benzyl p-hydroxyphenyl ether; Carmifal(TN); Depigman (TN); Dermochinona (TN); HYDROQUINONE MONOBENZYL ETHER, N F; Leucodinine (TN); Monobenzon (TN); Monobenzona [INN-Spanish]; Monobenzonum [INN-Latin]; Novo-depigman; P-BENZYLOXYPHENOL; P-Hydroxyphenyl benzyl ether; Pigmex (TN); Superlite (TN); Superlite (antioxidant); Monobenzone (USP/INN); P-(BENZYLOXY)PHENOL; 4-(Benzyl-Oxy)Phenol; 4-(Benzyloxy)phenol; 4-(Benzyloxyl)phenol; 4-(Phenylmethoxy)phenol; 4-Benzyloxyphenol; 4-benzyloxy phenol; 4-phenylmethoxy-phenol; 4-phenylmethoxyphenol
• Therapeutic Class: Dermatologic Agents
• Cross-matching ID:
  PubChem CID: 7638
  ChEBI ID: CHEMBL1388
  CAS Number: CAS 103-16-2
  TTD Drug ID: D0H6TP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.14	0.00e+0	19/20 (95%)	HSD17B7;CYP27B1;MSMO1;...
Toxoplasmosis	2.04	1.27e-2	103/112 (91.96%)	LAMC1;HLA-DOB;SOCS1;...
TNF signaling pathway	2.00	8.48e-3	103/112 (91.96%)	CASP10;CCL20;CCL5;...
Intestinal immune network for IgA production	1.93	9.54e-3	38/48 (79.17%)	HLA-DOB;HLA-DQA1;TNFSF13;...
Herpes simplex virus 1 infection	1.93	7.63e-3	165/498 (33.13%)	CCL5;HLA-DOB;IFIH1;...
Inflammatory bowel disease	1.91	1.06e-2	58/65 (89.23%)	HLA-DOB;HLA-DQA1;STAT6;...
Measles	1.87	1.82e-2	133/139 (95.68%)	MX2;IFIH1;MX1;...
Leishmaniasis	1.86	1.75e-2	67/77 (87.01%)	CYBA;HLA-DOB;HLA-DQA1;...
Glycosaminoglycan degradation	1.84	1.84e-2	19/19 (100%)	GUSB;HGSNAT;GLB1;...
Th1 and Th2 cell differentiation	1.82	2.04e-2	80/92 (86.96%)	HLA-DOB;HLA-DQA1;STAT6;...
Epstein-Barr virus infection	1.77	3.01e-2	189/202 (93.56%)	USP7;CDKN1A;MDM2;...
Human papillomavirus infection	1.76	2.97e-2	284/331 (85.8%)	MX2;GNAS;CDKN1A;...
Influenza A	1.75	3.03e-2	156/172 (90.7%)	MX2;CCL5;HLA-DOB;...
ECM-receptor interaction	1.74	3.27e-2	80/88 (90.91%)	THBS2;LAMC1;ITGA6;...
Th17 cell differentiation	1.73	3.05e-2	95/107 (88.79%)	HLA-DOB;HLA-DQA1;STAT6;...
NF-kappa B signaling pathway	1.73	2.86e-2	90/104 (86.54%)	VCAM1;LTB;LYN;...
Notch signaling pathway	1.73	2.69e-2	49/59 (83.05%)	HEY1;NOTCH3;HES1;...
Asthma	1.71	3.53e-2	25/31 (80.65%)	HLA-DOB;HLA-DQA1;HLA-DMB;...
Antigen processing and presentation	1.70	3.55e-2	60/78 (76.92%)	HLA-DOB;CD8A;RFX5;...
Rheumatoid arthritis	1.68	3.82e-2	78/93 (83.87%)	CCL20;CCL5;HLA-DOB;...
Kaposi sarcoma-associated herpesvirus infection	1.68	3.64e-2	172/193 (89.12%)	CDKN1A;LYN;TCF7;...
Toll-like receptor signaling pathway	1.66	4.22e-2	94/104 (90.38%)	CCL5;IL1B;CTSK;...
Hepatitis B	1.65	4.59e-2	151/162 (93.21%)	CASP10;CDKN1A;IFIH1;...
Cell cycle	-1.64	4.81e-2	110/124 (88.71%)	BUB1B;MCM6;ORC1;...
Progesterone-mediated oocyte maturation	-1.66	4.41e-2	75/100 (75%)	MAPK10;AKT2;ANAPC2;...
Cysteine and methionine metabolism	-1.69	3.42e-2	43/50 (86%)	CTH;LDHA;APIP;...
Citrate cycle (TCA cycle)	-1.73	2.44e-2	30/30 (100%)	IDH3B;DLAT;SUCLG1;...
Aminoacyl-tRNA biosynthesis	-1.79	1.33e-2	15/66 (22.73%)	GATB;QRSL1;TARS2;...
Bacterial invasion of epithelial cells	-1.79	1.66e-2	59/77 (76.62%)	ARHGEF26;CLTA;ACTR3B;...
Pyruvate metabolism	-1.81	1.55e-2	41/47 (87.23%)	ALDH1B1;GRHPR;PC;...
DNA replication	-2.16	0.00e+0	34/36 (94.44%)	RNASEH1;RPA2;RNASEH2B;...
Ribosome biogenesis in eukaryotes	-2.25	0.00e+0	52/108 (48.15%)	NXT1;MDN1;RPP38;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲