Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVLHNI)

• Drug Name: Tridihexethyl Drug Info
• Synonyms: Pathilon; Propethonum; (3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium; 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
• Therapeutic Class: Anticholinergic Agents
• Cross-matching ID:
  PubChem CID: 20299
  ChEBI ID: CHEMBL9701
  CAS Number: CAS 60-49-1
  TTD Drug ID: D0OK5I

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
African trypanosomiasis	1.87	1.82e-2	32/37 (86.49%)	PLCB1;SELE;HBB;...
Porphyrin and chlorophyll metabolism	-1.65	4.78e-2	23/43 (53.49%)	HMOX1;UGT2B17;HCCS;...
Synthesis and degradation of ketone bodies	-1.68	4.18e-2	9/10 (90%)	HMGCS2;ACAT1;HMGCS1;...
Citrate cycle (TCA cycle)	-1.70	3.90e-2	30/30 (100%)	ACLY;ACO1;SDHD;...
Terpenoid backbone biosynthesis	-1.72	3.46e-2	18/22 (81.82%)	DHDDS;FDPS;IDI1;...
Glyoxylate and dicarboxylate metabolism	-1.78	1.96e-2	23/30 (76.67%)	ACO1;CAT;ACO2;...
Regulation of lipolysis in adipocytes	-1.83	1.45e-2	52/55 (94.55%)	ADCY6;GNAI3;PRKACG;...
Nitrogen metabolism	-1.86	8.15e-3	16/17 (94.12%)	CA7;CA6;CA12;...
Pyruvate metabolism	-1.86	6.21e-3	41/47 (87.23%)	ACACB;LDHA;ME2;...
Retinol metabolism	-1.92	1.81e-3	41/68 (60.29%)	UGT2B17;DHRS9;RETSAT;...
Ascorbate and aldarate metabolism	-1.93	2.17e-3	15/30 (50%)	UGT2B17;ALDH1B1;UGT2A3;...
Oxidative phosphorylation	-1.95	0.00e+0	93/133 (69.92%)	ATP5MC2;ATP4A;ATP6V1H;...
PPAR signaling pathway	-2.05	0.00e+0	66/74 (89.19%)	AQP7;GK2;ACSBG2;...
Tryptophan metabolism	-2.08	0.00e+0	35/42 (83.33%)	CYP1B1;ALDH1B1;DLST;...
Mineral absorption	-2.27	0.00e+0	48/60 (80%)	SLC8A2;CLCN2;ATOX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲