Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVM3Z0)

Drug Name
Iocetamic acid Drug Info
Synonyms
IOCETAMIC ACID; Cholebrine; Colebrina; Cholimil; Acidum jocetamicum; 16034-77-8; Acide iocetamique [INN-French]; Acidum iocetamicum [INN-Latin]; Acido iocetamico [INN-Spanish]; HSDB 3344; DRC 1201; EINECS 240-173-1; MP-620; MP 620; BRN 2171366; N-Acetyl-N-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine; N-Acetyl-N-(3-amino-2,4,6-triiodophenl)-2-methyl-beta-alanine; beta-Alanine, N-acetyl-N-(3-amino-2,4,6-triiodophenyl)-2-methyl-; Propanoic acid, 3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-
Cross-matching ID
PubChem CID
27648
ChEBI ID
CHEMBL91662
CAS Number
CAS 16034-77-8
TTD Drug ID
D0P5CD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.92 3.74e-2 52/108 (48.15%) NVL;IMP3;FBL;...
Measles 1.85 2.62e-2 133/139 (95.68%) HSPA8;TLR4;IKBKE;...
Inflammatory bowel disease 1.70 4.86e-2 58/65 (89.23%) TLR4;TLR2;HLA-DMB;...
Cytosolic DNA-sensing pathway 1.67 4.77e-2 52/63 (82.54%) IKBKE;AIM2;POLR1D;...
Regulation of lipolysis in adipocytes -1.72 1.27e-2 52/55 (94.55%) CGA;ADCY7;IRS2;...
Protein digestion and absorption -1.76 1.20e-2 78/103 (75.73%) SLC3A2;MEP1B;COL16A1;...
Cholinergic synapse -1.76 1.24e-2 99/113 (87.61%) KCNQ1;CACNA1D;ATF4;...
Fatty acid elongation -1.76 1.29e-2 19/27 (70.37%) ELOVL4;PPT2;HACD1;...
PPAR signaling pathway -1.78 1.15e-2 66/74 (89.19%) CPT1A;ACADM;CPT2;...
Axon guidance -1.79 9.59e-3 151/182 (82.97%) PARD6B;GSK3B;SLIT1;...
Synthesis and degradation of ketone bodies -1.80 7.99e-3 9/10 (90%) ACAT2;HMGCS2;ACAT1;...
Adrenergic signaling in cardiomyocytes -1.80 7.82e-3 130/150 (86.67%) ADCY7;PPP2R5E;ATP2B2;...
Glutamatergic synapse -1.80 8.17e-3 97/114 (85.09%) CACNA1D;PLA2G4C;PLCB2;...
Insulin secretion -1.83 6.85e-3 75/86 (87.21%) KCNN3;INS;CREB3L1;...
Propanoate metabolism -1.86 4.80e-3 30/34 (88.24%) ACOX1;BCKDHB;ACAT2;...
Cushing syndrome -1.86 5.05e-3 125/155 (80.65%) ITPR2;ARNT;ADCY7;...
GABAergic synapse -1.87 2.66e-3 76/89 (85.39%) SLC6A12;CACNA1D;GNB2;...
Pancreatic secretion -1.88 2.82e-3 87/102 (85.29%) CTRB2;ADCY1;ATP2A2;...
Glycine, serine and threonine metabolism -1.88 3.00e-3 31/40 (77.5%) SHMT2;SHMT1;GLDC;...
Steroid biosynthesis -1.89 2.40e-3 19/20 (95%) EBP;LSS;SC5D;...
Terpenoid backbone biosynthesis -1.89 2.57e-3 18/22 (81.82%) ACAT2;IDI1;HMGCS2;...
Butanoate metabolism -1.93 1.84e-3 23/28 (82.14%) ACADS;HMGCL;ECHS1;...
Amphetamine addiction -1.96 9.99e-4 57/69 (82.61%) DDC;PPP3CB;PPP1CC;...
Dopaminergic synapse -1.97 1.09e-3 115/132 (87.12%) GSK3B;DDC;PPP3CB;...
Endocrine and other factor-regulated calcium reabsorpti... -2.00 1.20e-3 49/53 (92.45%) PRKCB;ATP1B2;ATP2B1;...
Melanogenesis -2.01 0.00e+0 74/101 (73.27%) PLCB2;GNAI3;DVL1;...
Circadian entrainment -2.01 0.00e+0 85/97 (87.63%) MAPK3;GRIN2C;RPS6KA5;...
Proximal tubule bicarbonate reclamation -2.04 0.00e+0 21/23 (91.3%) CA2;SLC4A4;ATP1B2;...
Ovarian steroidogenesis -2.06 0.00e+0 41/51 (80.39%) HSD3B1;INS;PLA2G4C;...
Alanine, aspartate and glutamate metabolism -2.09 0.00e+0 27/37 (72.97%) GAD2;GFPT1;GOT1;...
Renin-angiotensin system -2.10 0.00e+0 20/23 (86.96%) PREP;CTSG;ATP6AP2;...
Cortisol synthesis and secretion -2.11 0.00e+0 58/65 (89.23%) HSD3B1;CREB3L1;PDE8B;...
Valine, leucine and isoleucine degradation -2.12 0.00e+0 42/48 (87.5%) PCCA;MCCC1;OXCT1;...
Aldosterone synthesis and secretion -2.21 0.00e+0 85/98 (86.73%) CACNA1D;ATF4;PLCB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 3.33uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H