Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVM6QR)

Drug Name
Lacosamide Drug Info
Synonyms
Erlosamide; Harkoseride; Vimpat; Erlosamide [INN]; Lacosamide [USAN]; ADD 234037; SPM 927; ADD-234037; SPM-927; SPM-929; Erlosamide, Vimpat, Lacosamide; Lacosamide (USAN/INN); (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
219078
ChEBI ID
CHEMBL135939
CAS Number
CAS 175481-36-4
TTD Drug ID
D05OFX
INTEDE Drug ID
DR0911
ACDINA Drug ID
D00346

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.43 0.00e+0 34/36 (94.44%) PCNA;MCM6;MCM4;...
Cell cycle 2.02 7.64e-3 110/124 (88.71%) PCNA;PRKDC;PLK1;...
Aminoacyl-tRNA biosynthesis 1.92 1.02e-2 15/66 (22.73%) FARSA;GATC;DARS2;...
Base excision repair 1.87 1.91e-2 29/33 (87.88%) PCNA;FEN1;PARP1;...
Nitrogen metabolism 1.74 4.58e-2 16/17 (94.12%) CA2;CPS1;GLUD2;...
Ether lipid metabolism 1.74 3.95e-2 32/49 (65.31%) LPCAT1;ENPP2;PLAAT3;...
Ribosome biogenesis in eukaryotes 1.73 3.49e-2 52/108 (48.15%) NVL;NOP56;RAN;...
Mismatch repair 1.68 4.77e-2 22/23 (95.65%) PCNA;RPA3;EXO1;...
RNA polymerase 1.68 4.24e-2 23/31 (74.19%) POLR3E;POLR2E;POLR1B;...
One carbon pool by folate 1.68 4.35e-2 15/20 (75%) TYMS;ALDH1L1;ATIC;...
Fanconi anemia pathway 1.67 4.10e-2 36/54 (66.67%) HES1;FANCG;RPA3;...
RNA transport 1.65 4.71e-2 128/186 (68.82%) EEF1A2;NUP155;RAN;...
Linoleic acid metabolism 1.64 4.64e-2 21/29 (72.41%) PLAAT3;PLA2G4A;PLA2G12A;...
Proximal tubule bicarbonate reclamation 1.63 4.69e-2 21/23 (91.3%) SLC4A4;CA2;ATP1A2;...
Spliceosome 1.62 4.58e-2 101/150 (67.33%) HSPA8;HNRNPM;LSM5;...
Steroid biosynthesis -1.74 2.80e-2 19/20 (95%) SC5D;LSS;CYP24A1;...
NF-kappa B signaling pathway -1.75 2.51e-2 90/104 (86.54%) CD40LG;LTB;CXCL12;...
NOD-like receptor signaling pathway -1.78 1.92e-2 145/181 (80.11%) IRF7;NLRP3;TYK2;...
Osteoclast differentiation -1.78 2.13e-2 117/127 (92.13%) TNFRSF11B;JUNB;IKBKG;...
Other glycan degradation -1.79 2.40e-2 13/18 (72.22%) MAN2B2;AGA;ENGASE;...
Cell adhesion molecules -1.81 2.05e-2 118/148 (79.73%) NEO1;CD40LG;JAM2;...
Viral protein interaction with cytokine and cytokine re... -1.82 2.00e-2 84/100 (84%) CCL7;CCR10;IL20RA;...
Vibrio cholerae infection -1.84 2.16e-2 44/50 (88%) ATP6V1D;PRKACA;TJP1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.91 8.99e-3 62/70 (88.57%) JAM2;ADAM10;TJP1;...
Rheumatoid arthritis -1.96 4.00e-3 78/93 (83.87%) ITGAL;ACP5;ATP6V1D;...
TNF signaling pathway -1.99 0.00e+0 103/112 (91.96%) BIRC3;CREB1;LIF;...
IL-17 signaling pathway -2.06 0.00e+0 84/94 (89.36%) IKBKB;ELAVL1;CASP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H