Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVMIK2)

• Drug Name: Roxithromycin Drug Info
• Synonyms: Assoral; Overall; RXM; Rossitrol; Roxithromycine; Roxithromycinum; Roxitromicina; Rulid; Rulide; Surlid; Roxithromycine [French]; Roxithromycinum [Latin]; Roxitromicina [Spanish]; RC2952; RU 28965; RU 965; Biaxsig (TN); Coroxin (TN); RU-28965; RU-965; Roxar (TN); Roximycin (TN); Roxithromycin & Tumor Necrosis Factor; Roxo (TN); Rulide (TN); Surlid (TN); Tirabicin (TN); Roxithromycin [USAN:INN:JAN]; Roxl-150 (TN); Roxithromycin (JP15/USAN/INN); Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime);Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime); Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime); 9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin; 9-[O-(2-methoxyethoxymethyl)-oxime] of erythromycin
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6915744
  ChEBI ID: CHEMBL1214185
  CAS Number: CAS 80214-83-1
  TTD Drug ID: D0Y4FL
  VARIDT Drug ID: DR00708
  INTEDE Drug ID: DR1448

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.21	0.00e+0	44/46 (95.65%)	PSMD12;PSMC3;PSMC6;...
DNA replication	2.08	0.00e+0	34/36 (94.44%)	PCNA;PRIM1;MCM7;...
Systemic lupus erythematosus	2.06	0.00e+0	45/135 (33.33%)	C3;SNRPB;SNRPD3;...
Asthma	2.03	0.00e+0	25/31 (80.65%)	HLA-DQB1;HLA-DQA1;HLA-DPB1;...
Intestinal immune network for IgA production	1.98	1.78e-3	38/48 (79.17%)	HLA-DQB1;HLA-DQA1;HLA-DPB1;...
Spliceosome	1.95	2.96e-3	101/150 (67.33%)	HSPA8;HNRNPM;SNRPB;...
Base excision repair	1.87	5.08e-3	29/33 (87.88%)	PCNA;FEN1;APEX1;...
Ribosome biogenesis in eukaryotes	1.86	5.56e-3	52/108 (48.15%)	FBL;RCL1;NOP56;...
Cell cycle	1.84	7.90e-3	110/124 (88.71%)	PCNA;CDC20;ORC1;...
Hematopoietic cell lineage	1.74	3.20e-2	90/99 (90.91%)	IL7R;TFRC;IL11;...
Mismatch repair	1.71	4.20e-2	22/23 (95.65%)	PCNA;EXO1;MSH2;...
Steroid biosynthesis	1.71	3.85e-2	19/20 (95%)	DHCR24;LBR;TM7SF2;...
Type I diabetes mellitus	1.68	4.17e-2	38/43 (88.37%)	HLA-DQB1;HLA-DQA1;HLA-DPB1;...
Allograft rejection	1.65	4.89e-2	32/38 (84.21%)	HLA-DQB1;HLA-DQA1;HLA-DPB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼