Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVN5OH)

• Drug Name: Minocycline Drug Info
• Synonyms: Borymycin; MINO; MIY; Minociclina; Minociclinum; Minocin; Minocline; Minocyclin; Minocyclinum; Minocycline Monohydrochloride; CL 59806; Lactoferrin B & Minocycline; Lactoferrin H & Minocycline; Minociclina [INN-Spanish]; Minocin (Hydrochloride); Minocin (TN); Minocyclinum [INN-Latin]; Vectrin (Hydrochloride); CRL-1605 & Minocycline; Minocycline (USAN/INN); Minocycline [USAN:BAN:INN]; (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 54675783
  ChEBI ID: CHEMBL50694
  CAS Number: CAS 10118-90-8
  TTD Drug ID: D08LTU
  VARIDT Drug ID: DR00568
  ACDINA Drug ID: D00437

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
TNF signaling pathway	2.02	0.00e+0	103/112 (91.96%)	CXCL2;CCL20;NFKBIA;...
Systemic lupus erythematosus	-1.70	3.99e-2	45/135 (33.33%)	C8G;RO60;HLA-DOB;...
Glutathione metabolism	-1.73	3.19e-2	43/57 (75.44%)	SMS;PGD;GSTP1;...
Staphylococcus aureus infection	-1.73	3.67e-2	72/95 (75.79%)	IL10;PTAFR;PLG;...
Bacterial invasion of epithelial cells	-1.78	2.39e-2	59/77 (76.62%)	ACTR3;DNM1;CTTN;...
Antigen processing and presentation	-1.83	1.59e-2	60/78 (76.92%)	CTSL;HLA-G;HLA-DMB;...
Lysosome	-2.09	0.00e+0	115/128 (89.84%)	ATP6V0B;NAGA;AP1B1;...
Protein processing in endoplasmic reticulum	-2.18	0.00e+0	127/171 (74.27%)	NGLY1;PPP1R15A;DNAJC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼