Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVOY6B)

Drug Name
AMD-070 Drug Info
Synonyms
AMD 070; AMD070; AMD11070; S14-0353; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate
Cross-matching ID
PubChem CID
11256587
ChEBI ID
CHEMBL518924
CAS Number
CAS 558447-26-0
TTD Drug ID
D0O2XQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.08 0.00e+0 93/133 (69.92%) ATP5MC2;ATP5PD;COX5B;...
Mineral absorption 1.98 4.03e-3 48/60 (80%) MT1H;MT1G;MT1X;...
Ribosome 1.89 1.07e-2 113/158 (71.52%) RPS4Y1;RPS5;RPL29;...
Tyrosine metabolism 1.87 8.06e-3 30/36 (83.33%) TYRP1;ADH5;ADH1B;...
Steroid biosynthesis 1.83 1.13e-2 19/20 (95%) EBP;FDFT1;MSMO1;...
Vitamin digestion and absorption 1.76 2.55e-2 17/24 (70.83%) LMBRD1;SLC19A2;SLC5A6;...
TGF-beta signaling pathway 1.75 2.65e-2 81/94 (86.17%) INHBB;ID1;GREM1;...
RNA degradation 1.74 2.82e-2 53/79 (67.09%) PAN2;LSM5;BTG1;...
Synthesis and degradation of ketone bodies 1.69 4.48e-2 9/10 (90%) BDH2;ACAT2;HMGCS2;...
GnRH secretion -1.64 4.84e-2 60/64 (93.75%) TRPC4;KCNN3;TRPC1;...
Neutrophil extracellular trap formation -1.67 4.21e-2 101/189 (53.44%) C5AR1;PIK3R1;ITGAL;...
GnRH signaling pathway -1.67 4.45e-2 80/93 (86.02%) PRKCA;CAMK2B;GNAQ;...
Antigen processing and presentation -1.67 4.58e-2 60/78 (76.92%) RFX5;TAPBP;NFYA;...
Staphylococcus aureus infection -1.67 4.88e-2 72/95 (75.79%) C5AR1;ITGAL;KRT14;...
Hepatitis B -1.72 3.53e-2 151/162 (93.21%) IFNA17;PRKCA;TGFB1;...
Amoebiasis -1.73 3.52e-2 99/102 (97.06%) IL1B;PRKCA;GNAQ;...
RIG-I-like receptor signaling pathway -1.74 3.39e-2 64/70 (91.43%) IL12A;IFNA2;CXCL8;...
Legionellosis -1.74 3.48e-2 51/57 (89.47%) CLK4;SAR1B;EEF1A2;...
Natural killer cell mediated cytotoxicity -1.75 3.59e-2 99/131 (75.57%) PRF1;BRAF;IFNA14;...
Chagas disease -1.78 3.10e-2 93/102 (91.18%) PPP2CA;PPP2R1B;IKBKB;...
Human immunodeficiency virus 1 infection -1.78 3.55e-2 189/212 (89.15%) AP1B1;RAC3;TNFRSF1B;...
Herpes simplex virus 1 infection -1.85 2.07e-2 165/498 (33.13%) IFNAR2;IFNGR1;BCL2;...
Leishmaniasis -1.86 2.48e-2 67/77 (87.01%) IL4;HLA-DRB1;TRAF6;...
Toll-like receptor signaling pathway -1.86 2.79e-2 94/104 (90.38%) IRF5;TRAF6;IL1B;...
NOD-like receptor signaling pathway -1.88 2.48e-2 145/181 (80.11%) TRAF6;DEFA4;IL1B;...
Nicotine addiction -1.89 2.48e-2 32/40 (80%) GRIA1;GABRA6;GABRP;...
Tuberculosis -1.94 3.72e-2 159/180 (88.33%) IL1B;PPP3CC;FCGR3B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 3.33uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 10uM 24H