Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVPLJ7)

Drug Name
Sofalcone Drug Info
Synonyms Solon (TN)
Cross-matching ID
PubChem CID
5282219
ChEBI ID
CHEMBL135732
CAS Number
CAS 64506-49-6
TTD Drug ID
D06BLQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.41 0.00e+0 84/94 (89.36%) CXCL2;CXCL5;CXCL3;...
Viral protein interaction with cytokine and cytokine re... 2.01 1.22e-2 84/100 (84%) CXCL2;CXCL5;CXCL3;...
Rheumatoid arthritis 1.99 8.13e-3 78/93 (83.87%) CXCL2;CXCL5;CXCL3;...
TNF signaling pathway 1.89 1.52e-2 103/112 (91.96%) CXCL2;CXCL5;CXCL3;...
Phenylalanine metabolism 1.86 1.71e-2 14/17 (82.35%) ALDH3A1;GLYAT;MAOA;...
Epithelial cell signaling in Helicobacter pylori infect... 1.80 3.05e-2 62/70 (88.57%) CXCL2;CXCL3;CXCL8;...
Legionellosis 1.80 2.79e-2 51/57 (89.47%) CXCL2;CXCL3;CXCL8;...
NOD-like receptor signaling pathway 1.80 2.59e-2 145/181 (80.11%) CXCL2;CXCL3;CXCL8;...
DNA replication 1.79 2.71e-2 34/36 (94.44%) RFC5;MCM6;POLE3;...
Nucleotide excision repair 1.78 2.68e-2 40/47 (85.11%) RAD23B;RFC5;MNAT1;...
Chemokine signaling pathway 1.77 2.44e-2 163/192 (84.9%) CXCL2;CXCL5;CXCL3;...
Tyrosine metabolism 1.77 2.34e-2 30/36 (83.33%) ALDH3A1;GSTZ1;ADH6;...
Bladder cancer 1.73 3.10e-2 40/41 (97.56%) CXCL8;SRC;MMP1;...
Tryptophan metabolism 1.71 3.75e-2 35/42 (83.33%) KYNU;DLST;DHTKD1;...
Pentose and glucuronate interconversions 1.70 4.07e-2 17/34 (50%) AKR1B10;SORD;CRYL1;...
Primary bile acid biosynthesis 1.69 4.27e-2 15/17 (88.24%) ACOX2;CYP46A1;AMACR;...
NF-kappa B signaling pathway 1.68 4.66e-2 90/104 (86.54%) CXCL2;CXCL3;CXCL8;...
Lipid and atherosclerosis 1.68 4.47e-2 190/215 (88.37%) CXCL2;CXCL3;CXCL8;...
Neutrophil extracellular trap formation 1.66 4.94e-2 101/189 (53.44%) SRC;HAT1;VWF;...
Peroxisome 1.66 4.88e-2 72/82 (87.8%) ACOX2;CRAT;IDH2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H