Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVRH9C)

• Drug Name: Lomefloxacin Drug Info
• Synonyms: LFLX; Lomefloxacine; Lomefloxacino; Lomefloxacinum; Lomefloxacine [French]; Lomefloxacino [Spanish]; Lomefloxacinum[Latin]; SC 4711; SC 47111A; DM 10 (bactericide); DM-10; Lomefloxacin (USAN); Maxaquin (TN); Maxaquin (hydrochloride); Okacyn (TN); SC-4711; SC-47111A; Uniquin (TN); Lomefloxacin [USAN:BAN:INN]; NY-198 (hydrochloride); SC-47111 (hydrochloride); SC-47111B (mesylate); (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 3948
  ChEBI ID: CHEMBL116278
  CAS Number: CAS 98079-51-7
  TTD Drug ID: D02KOF
  VARIDT Drug ID: DR00507
  INTEDE Drug ID: DR0968

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	1.93	2.07e-2	76/85 (89.41%)	CFD;C3;SERPING1;...
ECM-receptor interaction	1.83	2.59e-2	80/88 (90.91%)	LAMB1;CD36;SDC4;...
Nicotine addiction	1.83	2.07e-2	32/40 (80%)	GABRP;GABRE;GABRB3;...
Lysine degradation	1.77	4.92e-2	51/63 (80.95%)	SUV39H1;MECOM;ALDH7A1;...
Adherens junction	1.76	4.77e-2	63/71 (88.73%)	MET;SNAI2;CTNNA2;...
Parkinson disease	-1.80	4.79e-2	176/249 (70.68%)	ATP5F1A;NDUFA4L2;KIF5B;...
Ribosome	-1.96	4.79e-3	113/158 (71.52%)	RPL6;RPL24;RPL5;...
Oxidative phosphorylation	-2.23	0.00e+0	93/133 (69.92%)	ATP5PO;ATP6V1E1;ATP6V0E1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼