Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVS9WQ)

• Drug Name: Nitisinone Drug Info
• Synonyms: Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 115355
  ChEBI ID: CHEMBL50378
  CAS Number: CAS 104206-65-7
  TTD Drug ID: D0V1UW
  ACDINA Drug ID: D00474

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ferroptosis	-1.76	4.96e-2	36/41 (87.8%)	ALOX15;MAP1LC3B;SAT1;...
Fatty acid degradation	-1.79	3.62e-2	40/43 (93.02%)	GCDH;ADH1B;ACOX3;...
Pentose phosphate pathway	-1.81	4.21e-2	25/30 (83.33%)	TKT;ALDOA;FBP1;...
Arginine biosynthesis	-1.87	4.31e-3	17/22 (77.27%)	GPT;NOS2;GLUD2;...
Alanine, aspartate and glutamate metabolism	-1.90	6.47e-3	27/37 (72.97%)	GPT;GLUD2;GLS2;...
Mineral absorption	-2.08	0.00e+0	48/60 (80%)	VDR;HEPH;MT2A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲