Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVSX6O)

Drug Name
Tebipenem Drug Info
Synonyms Tebipenem [INN]
Cross-matching ID
PubChem CID
9800194
CAS Number
CAS 161715-21-5
TTD Drug ID
D0Y6MH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.49 0.00e+0 34/36 (94.44%) MCM5;POLE2;FEN1;...
Mineral absorption 2.18 0.00e+0 48/60 (80%) MT1F;MT1M;MT1H;...
One carbon pool by folate 2.02 0.00e+0 15/20 (75%) TYMS;MTHFD1;SHMT2
Mismatch repair 1.99 3.26e-3 22/23 (95.65%) PCNA;RFC3;RFC4;...
Homologous recombination 1.96 3.92e-3 35/41 (85.37%) RAD51C;RAD54B;RPA3;...
Fanconi anemia pathway 1.92 6.53e-3 36/54 (66.67%) RAD51C;FANCG;FANCI;...
Cell cycle 1.88 6.53e-3 110/124 (88.71%) CDC45;MCM5;MAD2L1;...
Renin-angiotensin system 1.88 5.71e-3 20/23 (86.96%) CPA3;AGT;ANPEP;...
Purine metabolism 1.75 2.61e-2 102/129 (79.07%) RRM2;DCK;PRPS2;...
p53 signaling pathway 1.73 2.61e-2 63/73 (86.3%) RRM2;CCNG2;CDK1;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.72 3.03e-2 20/26 (76.92%) PIGF;GPAA1;PIGG;...
Base excision repair 1.70 3.15e-2 29/33 (87.88%) POLE2;FEN1;PCNA;...
Porphyrin and chlorophyll metabolism 1.70 2.91e-2 23/43 (53.49%) ALAS2;HEPH;HMBS;...
Butanoate metabolism 1.70 2.75e-2 23/28 (82.14%) ACAT2;HADH;GAD1;...
Nucleotide excision repair 1.66 3.44e-2 40/47 (85.11%) POLE2;PCNA;RFC3;...
Oocyte meiosis 1.63 3.96e-2 90/129 (69.77%) MAD2L1;ADCY3;CDK1;...
Glycine, serine and threonine metabolism 1.61 4.72e-2 31/40 (77.5%) PSPH;ALAS2;DLD;...
Cytokine-cytokine receptor interaction -1.75 4.25e-2 246/295 (83.39%) CCR6;IL5;IL24;...
Phagosome -1.76 4.35e-2 118/152 (77.63%) SFTPA2;TUBA1A;ATP6V0C;...
Estrogen signaling pathway -1.78 3.62e-2 119/137 (86.86%) KRT13;POMC;BCL2;...
Protein export -1.78 3.92e-2 17/23 (73.91%) SEC61A2;SEC63;SEC11A;...
Toll-like receptor signaling pathway -1.80 3.27e-2 94/104 (90.38%) CD86;TLR6;TLR8;...
Vasopressin-regulated water reabsorption -1.83 2.63e-2 40/44 (90.91%) DCTN4;DCTN2;AQP3;...
NOD-like receptor signaling pathway -1.88 2.00e-2 145/181 (80.11%) DEFB4A;HSP90AB1;GBP1;...
Amoebiasis -1.89 2.08e-2 99/102 (97.06%) ITGAM;PLCB1;PRKACB;...
Rheumatoid arthritis -1.89 2.18e-2 78/93 (83.87%) CCL5;HLA-DRA;CXCL6;...
Lipid and atherosclerosis -1.90 1.62e-2 190/215 (88.37%) ATF4;CYP2A6;IRF3;...
Viral protein interaction with cytokine and cytokine re... -1.93 1.66e-2 84/100 (84%) CCR6;IL24;CXCR4;...
TNF signaling pathway -2.02 6.92e-3 103/112 (91.96%) LTA;MAP2K4;IL18R1;...
Epithelial cell signaling in Helicobacter pylori infect... -2.07 4.61e-3 62/70 (88.57%) CCL5;RAC1;ADAM10;...
IL-17 signaling pathway -2.17 6.92e-3 84/94 (89.36%) MUC5AC;CSF3;TNFAIP3;...
Legionellosis -2.21 1.38e-2 51/57 (89.47%) HSPA2;SAR1B;HSPA8;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H