General Information of Drug (ID: DMVTHER)

Drug Name
Lincomycin Drug Info
Synonyms
Cillimycin; Epilincomycin; Jiemycin; LCM; Lincocin; Lincocine; Lincolcina; Lincolnensin; Lincomicina; Lincomix; Lincomycine; Lincomycinum; Lincomyocin; Lincorex; Mycivin; Lincomycin A; Lincomycine [French]; CBMicro_021584; Lincomix 20; Pura Ject 100; Lincocin (TN); Lincomicina [INN-Spanish]; Lincomycine [INN-French]; Lincomycinum [INN-Latin]; U 10,149A; Lincomycin (USAN/INN); Lincomycin [USAN:INN:BAN]; Lincomycin, (2S-cis)-Isomer; Methyl 6,8-dideoxy-6-[(1-methyl-4-propylprolyl)amino]-1-thiooctopyranoside
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
3000540
ChEBI ID
CHEMBL1447
CAS Number
CAS 154-21-2
TTD Drug ID
D0Q0EX
ACDINA Drug ID
D01210

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Citrate cycle (TCA cycle) 1.83 1.24e-1 30/30 (100%) PCK1;PCK2;CS;...
Steroid biosynthesis 1.83 6.21e-2 19/20 (95%) DHCR7;SQLE;TM7SF2;...
Staphylococcus aureus infection 1.82 5.18e-2 72/95 (75.79%) KRT23;C3;KRT18;...
Vitamin digestion and absorption 1.77 6.99e-2 17/24 (70.83%) APOB;SLC19A3;SLC19A1;...
Starch and sucrose metabolism 1.77 6.21e-2 25/36 (69.44%) GPI;UGP2;GYG1;...
Mitophagy 1.72 8.03e-2 56/68 (82.35%) CITED2;CSNK2B;GABARAPL1;...
Glycolysis / Gluconeogenesis 1.70 9.10e-2 56/67 (83.58%) PCK1;PGAM1;ALDH3A1;...
Phosphonate and phosphinate metabolism 1.67 1.07e-1 5/6 (83.33%) CHPT1
Mineral absorption 1.66 1.05e-1 48/60 (80%) MT1X;MT1G;MT1HL1;...
Bacterial invasion of epithelial cells 1.66 9.63e-2 59/77 (76.62%) FN1;CAV2;CAV1;...
Tyrosine metabolism 1.65 9.32e-2 30/36 (83.33%) ALDH3A1;TYR;TYRP1;...
Glyoxylate and dicarboxylate metabolism 1.64 9.58e-2 23/30 (76.67%) ACAT2;CS;DLD;...
Pyruvate metabolism 1.64 8.84e-2 41/47 (87.23%) ACAT2;PCK1;PCK2;...
Ferroptosis 1.64 8.54e-2 36/41 (87.8%) CP;ACSL1;SLC39A14;...
Phenylalanine metabolism 1.62 9.32e-2 14/17 (82.35%) ALDH3A1;PAH;DDC;...
Valine, leucine and isoleucine degradation 1.61 1.06e-1 42/48 (87.5%) ACAT2;DLD;MCCC1;...
Galactose metabolism 1.59 1.14e-1 26/31 (83.87%) AKR1B10;UGP2;PFKL;...
Tryptophan metabolism 1.56 1.45e-1 35/42 (83.33%) CYP1A1;ACAT2;DLD;...
PPAR signaling pathway 1.53 1.75e-1 66/74 (89.19%) FABP1;ACSL1;PCK1;...
Estrogen signaling pathway 1.53 1.71e-1 119/137 (86.86%) MMP9;KRT23;KRT18;...
Bladder cancer 1.50 2.05e-1 40/41 (97.56%) MMP9;E2F2;DAPK1;...
Shigellosis 1.48 2.15e-1 180/246 (73.17%) PFN2;C3;FOXO4;...
Nicotine addiction 1.47 2.27e-1 32/40 (80%) GRIA2;GABRA1;SLC17A6;...
GnRH secretion 1.46 2.33e-1 60/64 (93.75%) GNA11;PIK3CB;KCNN4;...
Systemic lupus erythematosus 1.44 2.57e-1 45/135 (33.33%) C3;ACTN1;SNRPB;...
Complement and coagulation cascades 1.44 2.49e-1 76/85 (89.41%) CLU;C3;CD59;...
Nicotinate and nicotinamide metabolism 1.43 2.55e-1 25/35 (71.43%) SIRT7;NT5C2;SIRT3;...
Pentose phosphate pathway 1.42 2.60e-1 25/30 (83.33%) GPI;PGD;TALDO1;...
Collecting duct acid secretion 1.42 2.66e-1 22/27 (81.48%) ATP6V0E2;ATP6V1D;ATP6V1B2;...
Cell cycle 1.39 3.03e-1 110/124 (88.71%) PCNA;E2F2;CDC45;...
cGMP-PKG signaling pathway -0.85 9.14e-1 145/167 (86.83%) GTF2IRD1;CREB3L1;BAD;...
Coronavirus disease -0.85 9.08e-1 215/232 (92.67%) RPS6;RPL7;TLR7;...
ABC transporters -0.86 9.16e-1 37/45 (82.22%) ABCD3;ABCC5;ABCB9;...
Vasopressin-regulated water reabsorption -0.86 9.22e-1 40/44 (90.91%) ADCY3;AQP3;PRKACB;...
Glioma -0.86 9.33e-1 67/75 (89.33%) TGFA;PDGFRB;CALML3;...
Amphetamine addiction -1.05 9.18e-1 57/69 (82.61%) PPP1CC;PRKCB;GRIA1;...
Oocyte meiosis -1.06 9.11e-1 90/129 (69.77%) MAPK13;INS;CDK1;...
Human papillomavirus infection -1.06 9.30e-1 284/331 (85.8%) KRAS;PPP2R2B;TSC1;...
Gap junction -1.18 8.37e-1 72/88 (81.82%) PLCB1;MAPK7;CDK1;...
Renin secretion -1.19 8.13e-1 61/69 (88.41%) PPP3CC;PRKACB;GUCY1B1;...
Basal cell carcinoma -1.21 7.75e-1 41/63 (65.08%) BAX;TCF7;FZD3;...
Transcriptional misregulation in cancer -1.22 7.69e-1 158/192 (82.29%) MET;CEBPA;NSD2;...
Chemokine signaling pathway -1.23 7.35e-1 163/192 (84.9%) CCL17;AKT1;PRKCB;...
NF-kappa B signaling pathway -1.26 6.42e-1 90/104 (86.54%) EDAR;PLAU;PRKCB;...
MicroRNAs in cancer -1.27 6.44e-1 146/310 (47.1%) FGFR3;TNN;BCL2L11;...
Type I diabetes mellitus -1.27 6.86e-1 38/43 (88.37%) INS;FAS;ICA1;...
Malaria -1.27 7.29e-1 44/50 (88%) HBB;TLR4;KLRK1;...
Thiamine metabolism -1.30 6.47e-1 12/15 (80%) TPK1;ALPL;AK4;...
Axon guidance -1.31 6.69e-1 151/182 (82.97%) PLXNA1;FZD3;EFNA5;...
Wnt signaling pathway -1.32 7.07e-1 124/166 (74.7%) CTNND2;SMAD3;CCN4;...
Various types of N-glycan biosynthesis -1.37 5.31e-1 26/39 (66.67%) MGAT2;ALG13;MAN1A2;...
Linoleic acid metabolism -1.38 5.54e-1 21/29 (72.41%) CYP2E1;PLA2G6;PLA2G1B;...
alpha-Linolenic acid metabolism -1.43 4.24e-1 17/25 (68%) PLA2G6;PLA2G1B;PLA2G12A;...
Protein digestion and absorption -1.45 4.08e-1 78/103 (75.73%) COL4A1;ELN;CELA3B;...
Viral protein interaction with cytokine and cytokine re... -1.46 4.73e-1 84/100 (84%) CCL24;CXCR4;CCR1;...
Ether lipid metabolism -1.51 3.51e-1 32/49 (65.31%) PLA2G6;PLD3;PLA2G1B;...
Arachidonic acid metabolism -1.55 3.30e-1 48/61 (78.69%) GGT1;CYP2E1;PLA2G6;...
Glycosaminoglycan biosynthesis -1.58 3.34e-1 40/58 (68.97%) HS3ST2;B3GAT3;CSGALNACT2;...
Ribosome -1.61 3.64e-1 113/158 (71.52%) RPL11;RPS6;RPL7;...
Taurine and hypotaurine metabolism -1.65 5.37e-1 8/11 (72.73%) GGT1;CDO1;GAD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 24H