Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVTSM8)

• Drug Name: Acefylline Drug Info
• Synonyms: Carboxymethyltheophylline; Theophyllin-7-ylacetic acid; Theophylline-7-acetic acid; Theophyllineacetic acid; (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid; 1,3-Dimethylxanthine-7-acetic acid; 2-(1,3-Dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetic acid; 652-37-9; 7-(Carboxymethyl)theophylline; 7-Theophyllineacetic acid; 7-Theophyllinessigsaeure; 7-Theophyllinylacetic acid; 7-Theophyllinylessigsaeure; Acefylline; Acephylline; BRN 0279221; EINECS 211-490-2; MFCD00022832; NSC 52996; UNII-M494UE2YEP
• Cross-matching ID:
  PubChem CID: 69550
  ChEBI ID: CHEMBL70246
  CAS Number: CAS 652-37-9
  INTEDE Drug ID: DR0034

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.30	0.00e+0	76/85 (89.41%)	C7;FGG;FGB;...
Retinol metabolism	2.28	0.00e+0	41/68 (60.29%)	ADH1B;ALDH1A3;CYP2C8;...
Metabolism of xenobiotics by cytochrome P450	2.07	0.00e+0	49/77 (63.64%)	CYP1B1;ADH1B;HSD11B1;...
Primary bile acid biosynthesis	2.06	0.00e+0	15/17 (88.24%)	AKR1C4;CYP39A1;SLC27A5;...
Nucleotide excision repair	2.03	0.00e+0	40/47 (85.11%)	MNAT1;RFC5;RFC3;...
Drug metabolism	2.01	0.00e+0	78/151 (51.66%)	ADH1B;CYP2C8;CYP2E1;...
PPAR signaling pathway	2.00	0.00e+0	66/74 (89.19%)	FADS2;SORBS1;PCK1;...
DNA replication	1.97	0.00e+0	34/36 (94.44%)	RFC5;RFC3;PRIM1;...
Steroid hormone biosynthesis	1.94	8.98e-4	43/61 (70.49%)	CYP1B1;HSD11B1;CYP2E1;...
Pyruvate metabolism	1.86	3.23e-3	41/47 (87.23%)	ADH1B;ALDH2;ADH1A;...
Linoleic acid metabolism	1.82	4.41e-3	21/29 (72.41%)	CYP2C8;CYP2E1;CYP3A4;...
Fatty acid degradation	1.78	7.40e-3	40/43 (93.02%)	ADH1B;ALDH2;ADH1A;...
Tyrosine metabolism	1.77	9.94e-3	30/36 (83.33%)	ADH1B;ALDH3A1;AOX1;...
Arachidonic acid metabolism	1.74	1.33e-2	48/61 (78.69%)	CYP2C8;CYP4F3;CYP2E1;...
Caffeine metabolism	1.71	2.05e-2	5/6 (83.33%)	CYP2A6;NAT1;CYP1A2;...
Prion disease	1.69	2.17e-2	209/273 (76.56%)	CAV2;C7;CAV1;...
Peroxisome	1.64	3.37e-2	72/82 (87.8%)	PHYH;AGXT;SLC27A2;...
Tryptophan metabolism	1.64	3.32e-2	35/42 (83.33%)	CYP1B1;AOX1;ALDH2;...
Glycolysis / Gluconeogenesis	1.62	3.83e-2	56/67 (83.58%)	ADH1B;ALDH3A1;ALDH2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲