Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVVAL4)

Drug Name
R112 Drug Info
Cross-matching ID
PubChem CID
9904854
ChEBI ID
CHEMBL515271
TTD Drug ID
D0L1PW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.19 0.00e+0 31/40 (77.5%) PHGDH;PSAT1;CBS;...
Cysteine and methionine metabolism 2.15 0.00e+0 43/50 (86%) PHGDH;PSAT1;CBS;...
One carbon pool by folate 2.01 1.07e-2 15/20 (75%) SHMT2;MTHFD2;MTHFD1
Alanine, aspartate and glutamate metabolism 1.99 1.20e-2 27/37 (72.97%) ASNS;ASS1;CPS1;...
Valine, leucine and isoleucine degradation 1.96 9.59e-3 42/48 (87.5%) ALDH6A1;ALDH2;BCAT1;...
Mucin type O-glycan biosynthesis 1.92 1.07e-2 20/36 (55.56%) GALNT6;GALNT12;GALNT10;...
beta-Alanine metabolism 1.89 9.13e-3 25/30 (83.33%) ALDH6A1;ALDH2;ALDH3A1;...
Pantothenate and CoA biosynthesis 1.88 7.99e-3 14/21 (66.67%) ALDH2;BCAT1;ENPP1;...
Arginine biosynthesis 1.73 4.53e-2 17/22 (77.27%) ASS1;CPS1;GOT1;...
Other types of O-glycan biosynthesis 1.73 4.16e-2 29/47 (61.7%) GALNT6;GALNT12;OGT;...
Selenocompound metabolism 1.73 3.85e-2 11/17 (64.71%) CTH;TXNRD1;SEPHS1;...
Proximal tubule bicarbonate reclamation 1.71 3.86e-2 21/23 (91.3%) PCK2;SLC4A4;ATP1A1;...
Lysosome 1.70 3.81e-2 115/128 (89.84%) NPC2;TPP1;AGA;...
Tryptophan metabolism 1.69 3.71e-2 35/42 (83.33%) ALDH2;DHTKD1;IDO1;...
Folate biosynthesis 1.68 3.62e-2 23/26 (88.46%) AKR1B10;AKR1C3;MOCOS;...
Spliceosome -1.76 2.80e-2 101/150 (67.33%) LSM2;SRSF1;SF3B1;...
Viral protein interaction with cytokine and cytokine re... -1.76 3.20e-2 84/100 (84%) CXCR4;ACKR3;IL20RA;...
Legionellosis -1.77 3.74e-2 51/57 (89.47%) BNIP3;HSPD1;SAR1A;...
Signaling pathways regulating pluripotency of stem cell... -1.77 4.49e-2 110/143 (76.92%) MAPK13;KLF4;ACVR1B;...
Biosynthesis of unsaturated fatty acids -1.78 4.99e-2 21/27 (77.78%) HACD2;SCP2;ELOVL4;...
Chagas disease -1.86 2.08e-2 93/102 (91.18%) GNAI1;MAPK13;CCL5;...
Proteasome -2.09 0.00e+0 44/46 (95.65%) PSMD13;PSMD7;PSME4;...
Steroid biosynthesis -2.37 0.00e+0 19/20 (95%) DHCR7;LSS;HSD17B7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H