Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVX9I0)

Drug Name
Des-Arg(9)-[Leu(8)]-BK Drug Info
Synonyms
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine; NBI 27914; NBI27914; NBI-27914; CHEMBL45281; SR-01000075865; Tocris-1591; Lopac-N-3911; AC1L41YH; Lopac0_000493; MLS000860080; cid_176157; GTPL3512; SCHEMBL16606734; CHEBI:93069; DTXSID20171549; HMS3261D07; HMS3371C20; HMS2230I15; ZINC2511843; Tox21_500493; BDBM50054245; CCG-204584; API0008466; LP00493; 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; NCGC00261178-01; NCGC00015737-05
Cross-matching ID
PubChem CID
176157
ChEBI ID
CHEMBL45281
CAS Number
CAS 184241-44-9
TTD Drug ID
D04KWH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arachidonic acid metabolism -1.61 4.73e-2 48/61 (78.69%) AKR1C3;PTGIS;CYP2J2;...
Adipocytokine signaling pathway -1.62 4.55e-2 64/69 (92.75%) CHUK;ACSL3;NFKBIB;...
PPAR signaling pathway -1.63 4.12e-2 66/74 (89.19%) SCD5;NR1H3;ACSL3;...
Renin-angiotensin system -1.63 4.34e-2 20/23 (86.96%) THOP1;PRCP;ANPEP;...
Biosynthesis of unsaturated fatty acids -1.66 3.54e-2 21/27 (77.78%) ELOVL5;HSD17B4;SCD5;...
Terpenoid backbone biosynthesis -1.68 2.98e-2 18/22 (81.82%) MVK;MVD;ICMT;...
Histidine metabolism -1.69 2.93e-2 16/22 (72.73%) ALDH9A1;ALDH3A2;HNMT;...
Drug metabolism -1.72 2.25e-2 78/151 (51.66%) ADH6;ALDH3A1;FMO2;...
Ferroptosis -1.74 1.54e-2 36/41 (87.8%) NCOA4;GCLM;GCLC;...
Steroid hormone biosynthesis -1.77 1.44e-2 43/61 (70.49%) CYP3A7;SULT2B1;CYP11B2;...
Arginine biosynthesis -1.78 1.56e-2 17/22 (77.27%) GLUD1;GLS2;OTC;...
Caffeine metabolism -1.78 1.62e-2 5/6 (83.33%) NAT1;NAT2;CYP1A2;...
Metabolism of xenobiotics by cytochrome P450 -1.84 6.56e-3 49/77 (63.64%) AKR7A2;GSTM2;CYP2F1;...
Nitrogen metabolism -1.84 7.29e-3 16/17 (94.12%) GLUD2;GLUL;CPS1;...
Tyrosine metabolism -1.87 7.03e-3 30/36 (83.33%) DCT;ADH6;ALDH3A1;...
Linoleic acid metabolism -1.88 4.02e-3 21/29 (72.41%) CYP2J2;PLA2G10;CYP3A4;...
Ovarian steroidogenesis -1.91 4.69e-3 41/51 (80.39%) IGF1;HSD3B2;ADCY3;...
Retinol metabolism -1.93 5.62e-3 41/68 (60.29%) PNPLA4;DHRS9;RETSAT;...
Complement and coagulation cascades -1.95 4.69e-3 76/85 (89.41%) F11;C5;PROCR;...
Bile secretion -1.97 3.12e-3 68/90 (75.56%) SLCO1B3;UGT2B4;KCNN2;...
Regulation of lipolysis in adipocytes -2.09 0.00e+0 52/55 (94.55%) PTGER3;ADCY1;PIK3CA;...
Steroid biosynthesis -2.19 0.00e+0 19/20 (95%) LIPA;EBP;SOAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H