Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVXKMF)

Drug Name
L-732138 Drug Info
Synonyms
L-732,138; 148451-96-1; 3,5-Bis(tfm)Bz nactrp; L-732138; 3,5-Bis(trifluoromethyl)benzyl N-acetyltryptophan; N-Acetyltryptophan 3,5-bis(trifluoromethyl)benzyl ester; L 732138; CHEMBL22870; N-Acetyl-L-trp-3,5-bistrifluoromethylbenzyl ester; L732138; N-Acetyl-L-tryptophan-3,5-bistrifluoromethylbenzyl ester; N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester; [3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-indol-3-yl)propanoate; AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER; L-Tryptophan, N-acetyl-, (3,5-
Cross-matching ID
PubChem CID
132837
ChEBI ID
CHEMBL22870
CAS Number
CAS 148451-96-1
TTD Drug ID
D08ZBV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 2.20 0.00e+0 25/31 (80.65%) CD40;RNASE3;HLA-DRB1;...
Allograft rejection 2.17 0.00e+0 32/38 (84.21%) CD40;HLA-DRB1;HLA-B;...
Type I diabetes mellitus 2.16 0.00e+0 38/43 (88.37%) CPE;HLA-DRB1;HLA-B;...
Autoimmune thyroid disease 1.87 1.32e-2 46/53 (86.79%) CD40;HLA-DRB1;HLA-B;...
Intestinal immune network for IgA production 1.84 1.76e-2 38/48 (79.17%) CD40;HLA-DRB1;ITGA4;...
Base excision repair 1.76 3.09e-2 29/33 (87.88%) NEIL3;POLE3;PARP2;...
Steroid hormone biosynthesis -1.86 1.95e-2 43/61 (70.49%) HSD3B2;AKR1D1;CYP1A2;...
Ferroptosis -1.91 7.43e-3 36/41 (87.8%) STEAP3;FTL;MAP1LC3B;...
Complement and coagulation cascades -2.03 1.11e-2 76/85 (89.41%) CD55;A2M;C9;...
PPAR signaling pathway -2.17 0.00e+0 66/74 (89.19%) SCD5;ANGPTL4;ACSBG2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H