Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMVZL26)

Drug Name
3,4-Dihydroxycinnamic Acid Drug Info
Synonyms
Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
Cross-matching ID
PubChem CID
689043
ChEBI ID
CHEMBL145
CAS Number
CAS 331-39-5
TTD Drug ID
D0V9EN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.62 0.00e+0 127/171 (74.27%) HERPUD1;P4HB;DDIT3;...
Protein export 2.34 0.00e+0 17/23 (73.91%) HSPA5;SEC61A1;SEC63;...
Lysosome 2.19 0.00e+0 115/128 (89.84%) IGF2R;LAPTM4A;PSAP;...
Various types of N-glycan biosynthesis 2.14 2.62e-3 26/39 (66.67%) RPN2;RPN1;STT3A;...
Ferroptosis 2.12 2.10e-3 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
N-Glycan biosynthesis 2.07 1.75e-3 38/50 (76%) RPN2;RPN1;STT3A;...
Vibrio cholerae infection 1.99 5.99e-3 44/50 (88%) SEC61A1;KDELR2;PDIA4;...
Phagosome 1.96 5.24e-3 118/152 (77.63%) CANX;SEC61A1;HLA-C;...
Antigen processing and presentation 1.95 4.66e-3 60/78 (76.92%) PDIA3;HSPA5;CANX;...
Glycosaminoglycan degradation 1.89 9.43e-3 19/19 (100%) GNS;HEXB;HEXA;...
Graft-versus-host disease 1.88 9.53e-3 32/42 (76.19%) HLA-C;HLA-B;HLA-F;...
Other glycan degradation 1.85 1.05e-2 13/18 (72.22%) AGA;HEXB;HEXA;...
Thyroid hormone synthesis 1.80 2.18e-2 66/75 (88%) HSPA5;CANX;HSP90B1;...
MicroRNAs in cancer 1.73 3.97e-2 146/310 (47.1%) HMOX1;DDIT4;VEGFA;...
HIF-1 signaling pathway 1.71 4.19e-2 105/109 (96.33%) HMOX1;VEGFA;EIF4EBP1;...
Type I diabetes mellitus 1.71 4.00e-2 38/43 (88.37%) HLA-C;HLA-B;HLA-F;...
Propanoate metabolism -1.72 4.21e-2 30/34 (88.24%) ACADS;EHHADH;BCKDHB;...
Ribosome biogenesis in eukaryotes -1.73 4.55e-2 52/108 (48.15%) REXO2;GAR1;DKC1;...
RNA polymerase -1.74 4.68e-2 23/31 (74.19%) POLR1C;POLR2H;POLR3B;...
Terpenoid backbone biosynthesis -1.83 3.75e-2 18/22 (81.82%) FDPS;ACAT1;ACAT2;...
Steroid biosynthesis -1.89 2.81e-2 19/20 (95%) LIPA;LSS;SC5D;...
Spliceosome -1.94 4.68e-2 101/150 (67.33%) SYF2;SF3B4;SF3A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 10uM - 100uM 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 100uM 6H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 6H, 24H