Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW2KI5)

Drug Name
24(S), 25-epoxycholesterol Drug Info
Synonyms 24,25-epoxy-cholesterol
Cross-matching ID
PubChem CID
3247059
ChEBI ID
CHEMBL434302
CAS Number
CAS 77058-74-3
TTD Drug ID
D0Q2RP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 2.16 0.00e+0 45/135 (33.33%) C3;C1QB;C1QA;...
Mineral absorption 1.98 0.00e+0 48/60 (80%) MT1M;MT1E;MT1F;...
Ribosome 1.97 0.00e+0 113/158 (71.52%) MRPS7;MRPS12;MRPL24;...
TGF-beta signaling pathway 1.82 3.37e-2 81/94 (86.17%) ID1;DCN;ID3;...
African trypanosomiasis 1.80 3.37e-2 32/37 (86.49%) HBB;IL18;IFNG;...
Histidine metabolism 1.79 3.19e-2 16/22 (72.73%) MAOB;ALDH2;MAOA;...
Glutathione metabolism -1.70 4.45e-2 43/57 (75.44%) GGCT;GPX4;LAP3;...
Fatty acid elongation -1.71 4.55e-2 19/27 (70.37%) ELOVL4;HSD17B12;HACD3;...
Terpenoid backbone biosynthesis -1.76 2.78e-2 18/22 (81.82%) GGPS1;PDSS2;MVD;...
Lysosome -1.76 2.93e-2 115/128 (89.84%) AP1G1;LIPA;CTSE;...
Epithelial cell signaling in Helicobacter pylori infect... -1.77 3.27e-2 62/70 (88.57%) ATP6V1C1;ATP6V1H;CDC42;...
PPAR signaling pathway -1.80 2.14e-2 66/74 (89.19%) CYP7A1;ACSL4;MMP1;...
Vibrio cholerae infection -1.81 2.23e-2 44/50 (88%) ATP6V0B;PDIA4;ATP6V1E1;...
Pentose phosphate pathway -1.85 1.48e-2 25/30 (83.33%) DERA;ALDOA;PFKL;...
Biosynthesis of unsaturated fatty acids -1.85 2.23e-2 21/27 (77.78%) HSD17B4;ELOVL6;TECR;...
Steroid biosynthesis -2.61 0.00e+0 19/20 (95%) EBP;HSD17B7;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H