Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW2SEV)

Drug Name
L-670596 Drug Info
Synonyms
121083-05-4; L-670,596; L-670596; L 670596; 2-(6,8-Difluoro-9-(4-(methylsulfonyl)benzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid; (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID; AC1L2VGU; SCHEMBL3044967; CHEBI:91930; CTK8F0755; MolPort-003-983-606; HMS3268M18; BCP28232; BN0288; AKOS022180202; RT-013483; FT-0757831; SR-01000597550; L002392; C-35484; SR-01000597550-1; J-004444; BRD-A85472596-001-01-4
Cross-matching ID
PubChem CID
129360
ChEBI ID
CHEMBL91930
CAS Number
CAS 121083-06-5
TTD Drug ID
D0AN1Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis -1.64 2.78e-2 56/67 (83.58%) ALDOA;PFKP;ENO2;...
Autoimmune thyroid disease -1.64 2.88e-2 46/53 (86.79%) HLA-DRB1;IL2;FAS;...
Viral myocarditis -1.65 2.88e-2 53/60 (88.33%) HLA-G;CASP3;DAG1;...
Arginine biosynthesis -1.66 2.75e-2 17/22 (77.27%) OTC;ARG2;GOT1;...
Hematopoietic cell lineage -1.68 2.65e-2 90/99 (90.91%) FCER2;CD3D;CD14;...
Type I diabetes mellitus -1.69 2.46e-2 38/43 (88.37%) HLA-DRB1;IL2;FAS;...
Retinol metabolism -1.69 2.56e-2 41/68 (60.29%) CYP3A5;HSD17B6;UGT2B15;...
Tryptophan metabolism -1.75 1.48e-2 35/42 (83.33%) DDC;CYP1A1;EHHADH;...
Legionellosis -1.77 1.29e-2 51/57 (89.47%) TLR2;SAR1B;CXCL8;...
Butanoate metabolism -1.78 1.27e-2 23/28 (82.14%) BDH1;HMGCL;EHHADH;...
Arginine and proline metabolism -1.78 1.28e-2 39/50 (78%) P4HA1;ALDH1B1;OAT;...
Histidine metabolism -1.79 1.26e-2 16/22 (72.73%) HAL;ALDH3B1;ALDH1B1;...
Pyruvate metabolism -1.83 9.68e-3 41/47 (87.23%) GLO1;ADH1C;PDHB;...
Cytokine-cytokine receptor interaction -1.83 1.03e-2 246/295 (83.39%) LTA;BMPR2;CXCL9;...
Allograft rejection -1.87 6.31e-3 32/38 (84.21%) HLA-DRB1;IL2;FAS;...
Pantothenate and CoA biosynthesis -1.87 6.73e-3 14/21 (66.67%) ALDH1B1;DPYD;COASY;...
Phagosome -1.92 3.28e-3 118/152 (77.63%) STX7;DYNC1LI1;FCGR2C;...
beta-Alanine metabolism -1.93 3.53e-3 25/30 (83.33%) HADHA;SMOX;ABAT;...
Rheumatoid arthritis -1.95 3.82e-3 78/93 (83.87%) ATP6V1E1;CD86;TEK;...
Synthesis and degradation of ketone bodies -1.95 4.17e-3 9/10 (90%) BDH1;HMGCL;ACAT2;...
Steroid biosynthesis -1.96 4.59e-3 19/20 (95%) HSD17B7;SC5D;TM7SF2;...
Antigen processing and presentation -1.97 4.08e-3 60/78 (76.92%) HLA-G;HSP90AA1;HSPA5;...
PPAR signaling pathway -1.98 3.44e-3 66/74 (89.19%) GK;ACOX1;SLC27A2;...
Complement and coagulation cascades -1.99 3.93e-3 76/85 (89.41%) SERPINC1;ITGAX;F10;...
Metabolism of xenobiotics by cytochrome P450 -2.02 3.06e-3 49/77 (63.64%) CYP3A5;CYP2E1;UGT2B15;...
Malaria -2.09 1.83e-3 44/50 (88%) CSF3;IFNG;HGF;...
Graft-versus-host disease -2.10 2.29e-3 32/42 (76.19%) HLA-DRB1;IL2;FAS;...
Fatty acid degradation -2.17 0.00e+0 40/43 (93.02%) ACSL6;ACADSB;ACAA1;...
Viral protein interaction with cytokine and cytokine re... -2.18 0.00e+0 84/100 (84%) LTA;CXCL9;TNFRSF10C;...
Valine, leucine and isoleucine degradation -2.29 0.00e+0 42/48 (87.5%) BCAT2;BCKDHB;BCAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H