Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW3QGJ)

Drug Name
LM-94 Drug Info
Synonyms
Bilcolic; Bilicante; Hymecromone; Cantabilin; Cantabiline; Cholestil; Cholonerton; Coumarin 4; Crodimon; Cumarote-C; Eurogale; Himecromona; Hymecromon; Hymecromonum; Imecromone; Imecromone [DCIT]; Medilla; Mendiaxon; Omega 127; Pilot 447; Resocyanine; beta-Methylumbelliferone; 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-; 4-MU; 4-Methyl-7-hydroxycoumarin; 4-Methylumbelliferon; 4-methylumbelliferone; 7-HYDROXY-4-METHYLCOUMARIN; 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran; 7-Hydroxy-4-methyl-2H-chromen-2-one; 90-33-5; LM 94; NSC 19026; NSC 9408
Cross-matching ID
PubChem CID
5280567
ChEBI ID
CHEMBL12208
CAS Number
CAS 90-33-5
INTEDE Drug ID
DR0841

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA polymerase 2.14 0.00e+0 23/31 (74.19%) POLR2J;POLR2I;POLR2G;...
Ribosome 2.11 0.00e+0 113/158 (71.52%) RPL26L1;RPL36;MRPL12;...
Pentose phosphate pathway 2.06 0.00e+0 25/30 (83.33%) TKTL1;ALDOB;PFKP;...
Oxidative phosphorylation 2.05 0.00e+0 93/133 (69.92%) ATP6V0E2;NDUFA3;ATP5F1B;...
Tryptophan metabolism 1.91 3.71e-3 35/42 (83.33%) KYNU;DLD;IDO1;...
Primary bile acid biosynthesis 1.85 1.08e-2 15/17 (88.24%) AKR1D1;BAAT;CYP27A1;...
Drug metabolism 1.84 9.27e-3 78/151 (51.66%) NME4;CYP3A4;CYP2E1;...
Retinol metabolism 1.83 9.27e-3 41/68 (60.29%) ALDH1A2;CYP3A4;UGT2B28;...
Type I diabetes mellitus 1.83 8.24e-3 38/43 (88.37%) GZMB;IFNG;CD86;...
Graft-versus-host disease 1.80 1.02e-2 32/42 (76.19%) GZMB;IFNG;CD86;...
Arginine and proline metabolism 1.79 1.01e-2 39/50 (78%) CKB;GATM;AOC1;...
Lysine degradation 1.79 9.27e-3 51/63 (80.95%) PLOD2;DLD;BBOX1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.77 9.98e-3 9/11 (81.82%) NQO1;COQ2;HPD;...
Propanoate metabolism 1.77 1.06e-2 30/34 (88.24%) DLD;ABAT;EHHADH;...
Allograft rejection 1.74 1.36e-2 32/38 (84.21%) GZMB;IFNG;CD86;...
Citrate cycle (TCA cycle) 1.73 1.56e-2 30/30 (100%) DLD;IDH2;DLST;...
Spliceosome 1.69 1.96e-2 101/150 (67.33%) LSM5;RBM25;CDC5L;...
Histidine metabolism 1.69 1.96e-2 16/22 (72.73%) AOC1;HNMT;ALDH3A2;...
beta-Alanine metabolism 1.68 1.95e-2 25/30 (83.33%) ABAT;EHHADH;ALDH6A1;...
Maturity onset diabetes of the young 1.63 3.11e-2 21/26 (80.77%) HHEX;PAX6;NR5A2;...
Glycolysis / Gluconeogenesis 1.63 3.09e-2 56/67 (83.58%) DLD;ALDOB;PFKP;...
Glycine, serine and threonine metabolism 1.62 3.20e-2 31/40 (77.5%) DLD;GATM;PIPOX;...
Amyotrophic lateral sclerosis 1.61 3.59e-2 267/364 (73.35%) GRIA2;NEFH;KIF5C;...
Metabolism of xenobiotics by cytochrome P450 1.57 4.94e-2 49/77 (63.64%) CYP3A4;CYP2E1;EPHX1;...
Glycosaminoglycan biosynthesis -1.72 4.85e-2 40/58 (68.97%) NDST3;EXT2;CHST12;...
MicroRNAs in cancer -1.77 2.48e-2 146/310 (47.1%) ROCK1;CCND1;CDKN1B;...
Toxoplasmosis -1.79 2.76e-2 103/112 (91.96%) IRAK4;HLA-DRA;CASP3;...
Legionellosis -1.79 3.19e-2 51/57 (89.47%) CXCL8;BCL2L13;CASP3;...
Malaria -1.90 1.06e-2 44/50 (88%) GYPC;LRP1;TGFB3;...
Regulation of lipolysis in adipocytes -1.98 1.06e-2 52/55 (94.55%) PRKACB;AQP7;ADCY6;...
ECM-receptor interaction -2.06 0.00e+0 80/88 (90.91%) SV2B;ITGB7;IBSP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H