Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW4X37)

• Drug Name: Diphenylpyraline Drug Info
• Synonyms: Allergen; Belfene; Dafen; Dayfen; Diafen; Difenilpiralina; Diphenylpyralamine; Diphenylpyralinum; Diphenylpyrilene; Hispril; Histryl; Histyn; Hystryl; Lergobine; Lyssipoll; Mepiben; Neargal; AN 1041; Difenilpiralina [INN-Spanish]; Diphenylpyraline (INN); Diphenylpyraline [INN:BAN]; Diphenylpyralinum [INN-Latin];Diphenylpyraline maleate (2:1); N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze; N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze [German]; 1-Methyl-4-piperidyl benzhydryl ether; 1-methyl-4-hydroxypiperidine benzhydryl ether; 4-(Benzhydryloxy)-1-methylpiperidine; 4-(Diphenylmethoxy)-1-methylpiperidine; 4-(benzhydryloxy)-N-methylpiperidine; 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE; 4-[(diphenylmethyl)oxy]-1-methylpiperidine; 4-benzhydryloxy-1-methylpiperidine
• Therapeutic Class: Antihistamines
• Cross-matching ID:
  PubChem CID: 3103
  ChEBI ID: CHEMBL1492
  CAS Number: CAS 147-20-6
  TTD Drug ID: D0W6DY
  INTEDE Drug ID: DR2281

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.26	0.00e+0	113/158 (71.52%)	RSL24D1;MRPL15;MRPL13;...
Oxidative phosphorylation	2.10	0.00e+0	93/133 (69.92%)	SDHD;NDUFAB1;NDUFB5;...
Hematopoietic cell lineage	1.87	1.28e-2	90/99 (90.91%)	CD9;MME;ANPEP;...
Drug metabolism	1.85	1.91e-2	78/151 (51.66%)	GSTO1;DPYD;NME1;...
Cardiac muscle contraction	1.83	1.84e-2	64/87 (73.56%)	COX7B;COX7A1;ATP1A2;...
Nitrogen metabolism	1.79	3.19e-2	16/17 (94.12%)	CA12;CA4;GLUL;...
Cocaine addiction	-1.69	3.60e-2	42/49 (85.71%)	RELA;CREB3L2;SLC18A2;...
Kaposi sarcoma-associated herpesvirus infection	-1.74	1.80e-2	172/193 (89.12%)	CCND1;ITPR2;AKT2;...
Toll-like receptor signaling pathway	-1.75	1.61e-2	94/104 (90.38%)	RELA;STAT1;TLR1;...
NF-kappa B signaling pathway	-1.77	1.63e-2	90/104 (86.54%)	BIRC3;CCL13;BIRC2;...
Aldosterone synthesis and secretion	-1.77	1.74e-2	85/98 (86.73%)	PRKCG;CREB5;GNAQ;...
Circadian entrainment	-1.78	1.78e-2	85/97 (87.63%)	GNB5;ADCY7;GUCY1B1;...
Cortisol synthesis and secretion	-1.80	1.63e-2	58/65 (89.23%)	CREB5;GNAQ;SP1;...
Parathyroid hormone synthesis, secretion and action	-1.82	1.35e-2	98/106 (92.45%)	PRKCG;CREB5;GNAQ;...
Amphetamine addiction	-1.82	1.47e-2	57/69 (82.61%)	CREB3L2;SIRT1;SLC18A2;...
NOD-like receptor signaling pathway	-1.83	1.12e-2	145/181 (80.11%)	TANK;BIRC3;TYK2;...
Lipid and atherosclerosis	-1.85	1.24e-2	190/215 (88.37%)	HSP90B1;RELA;TRAF3;...
Chemokine signaling pathway	-1.87	6.22e-3	163/192 (84.9%)	AKT2;CCR2;STAT2;...
Legionellosis	-1.88	7.10e-3	51/57 (89.47%)	VCP;RELA;ARF1;...
IL-17 signaling pathway	-1.92	4.14e-3	84/94 (89.36%)	JUND;S100A7;CSF2;...
Amoebiasis	-1.95	0.00e+0	99/102 (97.06%)	CD1C;CSF2;ARG1;...
Cytokine-cytokine receptor interaction	-2.00	0.00e+0	246/295 (83.39%)	TGFB1;CXCR3;IL17RC;...
Epithelial cell signaling in Helicobacter pylori infect...	-2.04	0.00e+0	62/70 (88.57%)	ATP6V0A1;ATP6V1G1;MET;...
Viral protein interaction with cytokine and cytokine re...	-2.14	0.00e+0	84/100 (84%)	IL20RA;CXCL11;IL6;...
TNF signaling pathway	-2.32	0.00e+0	103/112 (91.96%)	PIK3CB;CREB3L1;BIRC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼