Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW72NJ)

• Drug Name: ASP3026 Drug Info
• Synonyms: ASP3026; 1097917-15-1; ASP-3026; ASP 3026; N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine; UNII-HP4L6MXF10; HP4L6MXF10; 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine; MGGBYMDAPCCKCT-UHFFFAOYSA-N; MLS006011176; GTPL7740; SCHEMBL2827739; CHEMBL3545360; C29H40N8O3S; QCR-144; EX-A140; DTXSID90149038; AOB6601; MolPort-028-720-342; BCP06436; 2229AH; ZINC68120928; s8054
• Cross-matching ID:
  PubChem CID: 25134326
  ChEBI ID: CHEMBL3545360
  CAS Number: CAS 1097917-15-1
  TTD Drug ID: D09GEK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Asthma	2.24	0.00e+0	25/31 (80.65%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Intestinal immune network for IgA production	2.23	0.00e+0	38/48 (79.17%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Antigen processing and presentation	2.19	0.00e+0	60/78 (76.92%)	CD74;HLA-DRA;HLA-DPB1;...
Allograft rejection	2.14	0.00e+0	32/38 (84.21%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Graft-versus-host disease	2.07	0.00e+0	32/42 (76.19%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Protein digestion and absorption	2.01	0.00e+0	78/103 (75.73%)	COL5A2;COL9A3;COL6A1;...
Rheumatoid arthritis	1.94	0.00e+0	78/93 (83.87%)	HLA-DRA;CTSK;VEGFA;...
Autoimmune thyroid disease	1.93	0.00e+0	46/53 (86.79%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
ECM-receptor interaction	1.91	0.00e+0	80/88 (90.91%)	COL9A3;COL6A1;LAMA4;...
Primary immunodeficiency	1.88	7.15e-4	33/38 (86.84%)	CD40;RFX5;CD79A;...
Type I diabetes mellitus	1.85	1.95e-3	38/43 (88.37%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Transcriptional misregulation in cancer	1.84	1.79e-3	158/192 (82.29%)	PROM1;ARNT2;PLAT;...
Systemic lupus erythematosus	1.81	2.75e-3	45/135 (33.33%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Staphylococcus aureus infection	1.81	3.57e-3	72/95 (75.79%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Inflammatory bowel disease	1.79	4.76e-3	58/65 (89.23%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Sulfur metabolism	1.73	1.25e-2	9/10 (90%)	SELENBP1;TST;PAPSS2;...
Hematopoietic cell lineage	1.65	3.32e-2	90/99 (90.91%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
PI3K-Akt signaling pathway	1.64	3.53e-2	317/354 (89.55%)	ERBB3;PDGFRA;VEGFA;...
Phagosome	1.62	4.25e-2	118/152 (77.63%)	HLA-DRA;HLA-DPB1;HLA-DRB1;...
Glycine, serine and threonine metabolism	-1.75	4.72e-2	31/40 (77.5%)	GAMT;DAO;MAOA;...
Ribosome	-2.06	1.35e-2	113/158 (71.52%)	MRPL20;MRPL12;MRPS14;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲