Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW83TP)

Drug Name
Pimozide Drug Info
Synonyms
Antalon; Neoperidole; Opiran; Orap; Pimozida; Pimozidum; Primozida; ASTA Medica Brand of Pimozide; Janssen Brand of Pimozide;Orap forte; Pharmascience Brand of Pimozide; P 1793; R 6238; McN-JR 6238; Orap (TN); Pimozida [INN-Spanish]; Pimozidum [INN-Latin]; Primozida [INN-Spanish]; R-6238; McN-JR-6238; Pimozide (JAN/USP/INN); Pimozide [USAN:INN:BAN:JAN]; 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone; 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
Therapeutic ClassAntipsychotic Agents
Cross-matching ID
PubChem CID
16362
ChEBI ID
CHEMBL1423
CAS Number
CAS 2062-78-4
TTD Drug ID
D00KHM
VARIDT Drug ID
DR00484
INTEDE Drug ID
DR1291
ACDINA Drug ID
D00532

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.53 0.00e+0 19/20 (95%) SQLE;MSMO1;DHCR24;...
Terpenoid backbone biosynthesis 2.28 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Biosynthesis of unsaturated fatty acids 2.02 0.00e+0 21/27 (77.78%) SCD;FADS2;FADS1;...
Melanogenesis 2.01 0.00e+0 74/101 (73.27%) PLCB1;CALML5;CREB3L2;...
PPAR signaling pathway 1.97 2.27e-3 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Vitamin digestion and absorption 1.96 1.89e-3 17/24 (70.83%) APOB;APOA1;ABCC1;...
Cholesterol metabolism 1.88 6.48e-3 44/50 (88%) LDLR;APOB;APOA1;...
Ferroptosis 1.80 1.56e-2 36/41 (87.8%) HMOX1;SLC7A11;ACSL1;...
Riboflavin metabolism 1.73 3.28e-2 7/8 (87.5%) ENPP1;BLVRB;ACP5;...
Proximal tubule bicarbonate reclamation -1.57 4.44e-2 21/23 (91.3%) AQP1;ATP1B3;CA4;...
mRNA surveillance pathway -1.60 3.15e-2 71/98 (72.45%) CSTF3;TARDBP;GLE1;...
Antigen processing and presentation -1.63 2.65e-2 60/78 (76.92%) HLA-DPB1;HLA-DOB;TAP2;...
Cellular senescence -1.63 2.76e-2 139/156 (89.1%) MYBL2;RB1;MAP2K2;...
Legionellosis -1.63 2.85e-2 51/57 (89.47%) TNF;NFKB2;RELA;...
TNF signaling pathway -1.66 2.23e-2 103/112 (91.96%) JUNB;CCL5;CHUK;...
Spliceosome -1.70 1.63e-2 101/150 (67.33%) CTNNBL1;PPIE;SRSF3;...
Mineral absorption -1.71 1.32e-2 48/60 (80%) HMOX2;ATP2B2;ATP1A2;...
Thermogenesis -1.72 1.35e-2 173/232 (74.57%) NDUFS8;ATP5PB;RPS6;...
Epithelial cell signaling in Helicobacter pylori infect... -1.72 1.43e-2 62/70 (88.57%) ATP6V0A4;JAM3;HBEGF;...
Rheumatoid arthritis -1.73 1.36e-2 78/93 (83.87%) CXCL6;IL23A;TGFB3;...
IL-17 signaling pathway -1.75 1.28e-2 84/94 (89.36%) HSP90AA1;LCN2;FOSB;...
Non-alcoholic fatty liver disease -1.77 9.56e-3 126/155 (81.29%) COX6B1;COX6C;CASP7;...
Viral protein interaction with cytokine and cytokine re... -1.77 1.03e-2 84/100 (84%) IL18;CCL20;CXCL13;...
Autoimmune thyroid disease -1.77 1.12e-2 46/53 (86.79%) HLA-DPB1;PRF1;HLA-DOB;...
Allograft rejection -1.78 9.89e-3 32/38 (84.21%) HLA-DPB1;PRF1;HLA-DOB;...
Graft-versus-host disease -1.81 8.37e-3 32/42 (76.19%) HLA-G;IL1A;HLA-DPB1;...
Diabetic cardiomyopathy -1.82 9.30e-3 162/203 (79.8%) TGFB3;COX6B1;COX6C;...
Type I diabetes mellitus -1.90 5.23e-3 38/43 (88.37%) HLA-G;IL1A;HLA-DPB1;...
Huntington disease -1.92 5.98e-3 233/306 (76.14%) IFT57;SEM1;NDUFA1;...
Amyotrophic lateral sclerosis -1.95 5.58e-3 267/364 (73.35%) TARDBP;BECN1;PFN1;...
Prion disease -1.99 5.02e-3 209/273 (76.56%) C9;COX6B1;COX6C;...
Parkinson disease -2.06 0.00e+0 176/249 (70.68%) NDUFS8;PSMD12;ATP5PB;...
Ribosome -2.10 0.00e+0 113/158 (71.52%) RPL32;RPSA;RPL37A;...
Proteasome -2.19 0.00e+0 44/46 (95.65%) PSMB1;PSMA6;PSMA5;...
Oxidative phosphorylation -2.43 0.00e+0 93/133 (69.92%) COX6B1;COX6C;ATP5ME;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H