Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMW8YQQ)

Drug Name
Aclidinium Drug Info
Synonyms
Aclidinium; UNII-K17VY42F6C; K17VY42F6C; CHEBI:65346; 727649-81-2; CHEMBL551466; (3R)-3-[2-hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane; (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide; SCHEMBL72141; GTPL7449; SCHEMBL15096073; CHEMBL1194325; DTXSID00223070; ZINC30691727; BDBM50296331; DB08897; AJ-84146; AB01565828_02; 1-(3-Phenoxypropyl)-3alpha-[hydroxybis(2-thienyl)acetyloxy]-1-azoniabicyclo[2.2.2]octane
Cross-matching ID
PubChem CID
11434515
ChEBI ID
CHEMBL1194325
CAS Number
CAS 727649-81-2
TTD Drug ID
D0VP1V

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.22 0.00e+0 34/36 (94.44%) PCNA;FEN1;MCM3;...
Ribosome biogenesis in eukaryotes 2.00 3.78e-3 52/108 (48.15%) NVL;NOP56;POP7;...
Spliceosome 1.83 2.01e-2 101/150 (67.33%) HNRNPM;PUF60;CRNKL1;...
Fanconi anemia pathway 1.77 2.08e-2 36/54 (66.67%) RPA3;HES1;FANCG;...
Primary immunodeficiency 1.74 3.63e-2 33/38 (86.84%) IL7R;PTPRC;CD40;...
Mismatch repair 1.71 4.03e-2 22/23 (95.65%) PCNA;RFC3;EXO1;...
Cell cycle 1.70 3.89e-2 110/124 (88.71%) PCNA;CDC6;CDC25B;...
RNA polymerase 1.69 4.25e-2 23/31 (74.19%) POLR3G;POLR3K;POLR3B;...
Pentose and glucuronate interconversions -1.73 4.40e-2 17/34 (50%) SORD;AKR1A1;UGT2A3;...
Cholesterol metabolism -1.74 4.50e-2 44/50 (88%) MYLIP;LDLR;LIPC;...
Ferroptosis -1.75 4.11e-2 36/41 (87.8%) ACSL6;VDAC2;SLC11A2;...
Retinol metabolism -1.77 3.60e-2 41/68 (60.29%) CYP1A2;CYP1A1;DGAT1;...
Pentose phosphate pathway -1.78 3.36e-2 25/30 (83.33%) TKT;RGN;PFKP;...
Renin-angiotensin system -1.97 3.00e-3 20/23 (86.96%) ANPEP;ENPEP;ATP6AP2;...
Mineral absorption -2.00 0.00e+0 48/60 (80%) ATP1A1;FTL;SLC26A3;...
Lysosome -2.02 0.00e+0 115/128 (89.84%) CTSW;GNS;LAMP2;...
Other glycan degradation -2.04 0.00e+0 13/18 (72.22%) AGA;FUCA1;GLB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H