Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWALXQ)

Drug Name
bongkrek acid Drug Info
Synonyms bongkrekic acid; flavotoxin A
Cross-matching ID
PubChem CID
6433556
ChEBI ID
CHEMBL77742
CAS Number
CAS 11076-19-0
TTD Drug ID
D07GHW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyruvate metabolism 2.01 0.00e+0 41/47 (87.23%) DLD;PCK1;ADH1B;...
Nicotinate and nicotinamide metabolism -1.71 4.62e-2 25/35 (71.43%) SIRT5;SIRT3;NADSYN1;...
Complement and coagulation cascades -1.79 2.00e-2 76/85 (89.41%) A2M;F8;F9;...
Fatty acid elongation -1.81 2.22e-2 19/27 (70.37%) HADHB;HACD1;HADH;...
Fructose and mannose metabolism -1.82 2.77e-2 30/33 (90.91%) GMPPA;PFKFB2;ALDOB;...
Salivary secretion -1.88 2.16e-2 76/93 (81.72%) PLCB4;CALML5;MUC7;...
Cholesterol metabolism -2.01 4.62e-3 44/50 (88%) LIPC;LRPAP1;LPA;...
Steroid biosynthesis -2.14 9.24e-3 19/20 (95%) SOAT1;LIPA;SOAT2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 1.11uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H