Details of the Drug Pharmacogenomic Perturbation Atlas

Olprinone Drug Info

Olprinone; 106730-54-5; loprinone; Coretec; Olprinone [INN]; UNII-4Y8BMI9YGC; 4Y8BMI9YGC; C14H10N4O; Olprinone (INN); 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile; 1,2-Dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile; 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridinecarbonitrile; AC1L1IIG; AC1Q4Q1U; SCHEMBL27661; DTXSID1048461; CHEMBL1474900; KS-00000EYK; MolPort-006-394-808; JPAWFIIYTJQOKW-UHFFFAOYSA-N; CHEBI:135019; BCP09781; ZINC38192538; HY-14254A; 3950AH

Cross-matching ID

PubChem CID

4593

ChEBI ID

CHEMBL135019

CAS Number

CAS 106730-54-5

TTD Drug ID

D03ZBN

General Information of Drug (ID: DMWBQKU)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein export	2.16	1.06e-2	17/23 (73.91%)	OXA1L;SRPRB;HSPA5;...
DNA replication	2.08	5.29e-3	34/36 (94.44%)	RFC5;RFC4;RPA3;...
Nucleotide excision repair	2.05	1.06e-2	40/47 (85.11%)	RAD23B;RFC5;CUL4B;...
Pentose phosphate pathway	2.01	7.94e-3	25/30 (83.33%)	ALDOB;PFKP;PRPS1;...
Dopaminergic synapse	1.89	1.06e-2	115/132 (87.12%)	GNAI1;GRIA2;CACNA1A;...
Nitrogen metabolism	1.84	2.29e-2	16/17 (94.12%)	GLUL;CA12;CA8;...
Mismatch repair	1.81	2.57e-2	22/23 (95.65%)	RFC5;RFC4;RPA3;...
Glutamatergic synapse	1.81	2.25e-2	97/114 (85.09%)	GNAI1;GRIA2;SLC1A1;...
Thiamine metabolism	1.79	2.47e-2	12/15 (80%)	AK4;AK2;TPK1;...
Peroxisome	1.77	3.07e-2	72/82 (87.8%)	ECI2;AMACR;SLC27A2;...
RNA transport	1.76	2.89e-2	128/186 (68.82%)	EIF4B;EIF4A3;CLNS1A;...
Serotonergic synapse	1.76	2.65e-2	97/114 (85.09%)	GNAI1;ALOX5;CACNA1A;...
Circadian entrainment	1.70	4.48e-2	85/97 (87.63%)	GNAI1;GRIA2;PER1;...
Long-term depression	1.66	4.73e-2	55/60 (91.67%)	GNAI1;GRIA2;CACNA1A;...
Focal adhesion	-1.81	4.04e-2	180/201 (89.55%)	THBS2;HRAS;DOCK1;...
Intestinal immune network for IgA production	-1.84	2.85e-2	38/48 (79.17%)	HLA-DRB1;HLA-DRA;ITGA4;...
Ether lipid metabolism	-1.84	4.27e-2	32/49 (65.31%)	PLA2G12A;PLA2G2D;PLPP3;...
Cytosolic DNA-sensing pathway	-2.11	0.00e+0	52/63 (82.54%)	IFNA6;POLR3B;CHUK;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-ES-1	CVCL_0627	Homo sapiens	1.11uM - 10uM	24H

Brain

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	1.11uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-468	CVCL_0419	Homo sapiens	1.11uM - 10uM	24H

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
T-47D	CVCL_0553	Homo sapiens	1.11uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

SNU-407	CVCL_5004	Homo sapiens	1.11uM - 10uM	24H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 10uM	24H

HEC-1-A	CVCL_0293	Homo sapiens	1.11uM - 10uM	24H

HEC-251	CVCL_2928	Homo sapiens	1.11uM - 10uM	24H

HEC-265	CVCL_2929	Homo sapiens	1.11uM - 10uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CJM	CVCL_U797	Homo sapiens	1.11uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	1.11uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1573	CVCL_1483	Homo sapiens	1.11uM - 10uM	24H

NCI-H838	CVCL_1594	Homo sapiens	1.11uM - 10uM	24H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BEN	CVCL_1081	Homo sapiens	3.33uM - 10uM	24H

HCC95	CVCL_1276	Homo sapiens	1.11uM - 10uM	24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H2110	CVCL_1529	Homo sapiens	1.11uM - 10uM	24H

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	3.33uM - 10uM	24H

Ovary

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OVTOKO	CVCL_3114	Homo sapiens	1.11uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
22Rv1	CVCL_1045	Homo sapiens	3.33uM - 10uM	24H

PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

IGR-37	CVCL_1303	Homo sapiens	1.11uM - 10uM	24H

Mel-HO	CVCL_1402	Homo sapiens	1.11uM - 10uM	24H

SH-4	CVCL_1692	Homo sapiens	1.11uM - 10uM	24H

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	1.11uM - 10uM	24H

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	3.33uM - 10uM	24H