Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWBZJD)

Drug Name
GDC-0068 Drug Info
Synonyms RG7440
Cross-matching ID
PubChem CID
24788740
ChEBI ID
CHEMBL95089
CAS Number
CAS 1001264-89-6
TTD Drug ID
D0I4TH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Transcriptional misregulation in cancer 2.23 0.00e+0 158/192 (82.29%) DUSP6;PLAT;MYC;...
ECM-receptor interaction 2.08 0.00e+0 80/88 (90.91%) ITGB5;THBS1;COL4A1;...
Proteoglycans in cancer 2.04 0.00e+0 172/205 (83.9%) MYC;ITGB5;PLAU;...
MicroRNAs in cancer 2.04 0.00e+0 146/310 (47.1%) MARCKS;MYC;IRS2;...
Focal adhesion 2.03 0.00e+0 180/201 (89.55%) ITGB5;THBS1;COL4A1;...
NF-kappa B signaling pathway 2.01 0.00e+0 90/104 (86.54%) PLAU;TLR4;CFLAR;...
Viral protein interaction with cytokine and cytokine re... 1.98 0.00e+0 84/100 (84%) TNFSF10;IL2RG;CCL21;...
AGE-RAGE signaling pathway in diabetic complications 1.95 0.00e+0 97/100 (97%) EGR1;TGFBR2;TGFB1;...
Malaria 1.95 0.00e+0 44/50 (88%) TLR4;THBS1;TGFB1;...
TGF-beta signaling pathway 1.93 0.00e+0 81/94 (86.17%) MYC;TGIF1;THBS1;...
Complement and coagulation cascades 1.88 2.75e-3 76/85 (89.41%) F2R;PLAT;TFPI;...
Pyrimidine metabolism 1.86 3.36e-3 40/56 (71.43%) NT5E;DUT;DPYD;...
Small cell lung cancer 1.85 3.88e-3 90/92 (97.83%) MYC;COL4A1;FN1;...
PI3K-Akt signaling pathway 1.84 4.32e-3 317/354 (89.55%) F2R;GNG11;MYC;...
Amoebiasis 1.82 5.38e-3 99/102 (97.06%) TLR4;SERPINB6;TGFB1;...
FoxO signaling pathway 1.81 5.04e-3 118/131 (90.08%) IRS2;TNFSF10;SGK1;...
Natural killer cell mediated cytotoxicity 1.78 1.13e-2 99/131 (75.57%) TNFSF10;PRF1;PRKCA;...
Inflammatory bowel disease 1.77 1.23e-2 58/65 (89.23%) TLR4;TGFB1;MAF;...
Wnt signaling pathway 1.76 1.33e-2 124/166 (74.7%) MYC;FRAT1;MMP7;...
Pathways in cancer 1.75 1.46e-2 474/531 (89.27%) F2R;GNG11;MYC;...
Osteoclast differentiation 1.74 1.49e-2 117/127 (92.13%) TGFBR2;TGFB1;FOSB;...
Signaling pathways regulating pluripotency of stem cell... 1.72 1.65e-2 110/143 (76.92%) MYC;ID4;IGF1R;...
Th17 cell differentiation 1.70 2.11e-2 95/107 (88.79%) TGFBR2;TGFB1;AHR;...
Regulation of actin cytoskeleton 1.65 3.95e-2 185/218 (84.86%) F2R;ITGB5;GSN;...
Base excision repair 1.63 4.60e-2 29/33 (87.88%) POLD4;PCNA;LIG1;...
Cytokine-cytokine receptor interaction 1.62 4.89e-2 246/295 (83.39%) TNFSF10;CSF2RB;TGFBR2;...
Pyruvate metabolism -1.59 4.41e-2 41/47 (87.23%) DLAT;PCK2;FH;...
Folate biosynthesis -1.62 3.22e-2 23/26 (88.46%) PAH;CBR1;GPHN;...
Steroid hormone biosynthesis -1.65 2.68e-2 43/61 (70.49%) SULT2B1;UGT2A3;DHRS11;...
Aminoacyl-tRNA biosynthesis -1.67 2.58e-2 15/66 (22.73%) QRSL1;CARS2;NARS2;...
Thiamine metabolism -1.67 2.65e-2 12/15 (80%) ALPG;ALPP;AK4;...
Collecting duct acid secretion -1.69 2.42e-2 22/27 (81.48%) ATP6V0A1;ATP6V1E1;ATP6V0A2;...
Ribosome -1.69 2.53e-2 113/158 (71.52%) RPL9;RPS28;RPL32;...
Pathways of neurodegeneration -1.77 1.13e-2 354/475 (74.53%) FZD9;MTOR;NDUFB3;...
Arginine and proline metabolism -1.78 1.14e-2 39/50 (78%) ARG2;LAP3;MAOB;...
Alanine, aspartate and glutamate metabolism -1.79 1.09e-2 27/37 (72.97%) GFPT1;ABAT;GOT1;...
Alzheimer disease -1.79 1.16e-2 279/369 (75.61%) PSMC3;PSMB1;ITPR1;...
Huntington disease -1.83 8.62e-3 233/306 (76.14%) PSMC3;PSMB1;ITPR1;...
Valine, leucine and isoleucine degradation -1.84 9.19e-3 42/48 (87.5%) HIBCH;MCCC1;ACAA1;...
Tryptophan metabolism -1.88 7.03e-3 35/42 (83.33%) MAOB;TPH1;DDC;...
Basal transcription factors -1.89 6.06e-3 37/45 (82.22%) CCNH;MNAT1;GTF2A2;...
Amyotrophic lateral sclerosis -1.94 3.28e-3 267/364 (73.35%) ANXA7;MTOR;NDUFB3;...
Glycine, serine and threonine metabolism -1.98 1.79e-3 31/40 (77.5%) SRR;MAOB;SHMT2;...
Prion disease -1.98 1.97e-3 209/273 (76.56%) PSMC3;PSMB1;ITPR1;...
Ferroptosis -2.00 2.19e-3 36/41 (87.8%) TF;VDAC2;ACSL3;...
Protein export -2.01 1.23e-3 17/23 (73.91%) SEC11A;SRPRA;OXA1L;...
Citrate cycle (TCA cycle) -2.05 0.00e+0 30/30 (100%) SDHA;DLST;DLAT;...
Cysteine and methionine metabolism -2.09 0.00e+0 43/50 (86%) BHMT2;AHCY;AHCYL2;...
Oxidative phosphorylation -2.11 0.00e+0 93/133 (69.92%) ATP6V0A1;ATP6V0B;SDHD;...
Ribosome biogenesis in eukaryotes -2.12 0.00e+0 52/108 (48.15%) MPHOSPH10;NXF1;POP1;...
Proteasome -2.32 0.00e+0 44/46 (95.65%) PSMC3;PSMB1;PSME4;...
Parkinson disease -2.34 0.00e+0 176/249 (70.68%) PSMC3;PSMB1;ITPR1;...
Protein processing in endoplasmic reticulum -2.47 0.00e+0 127/171 (74.27%) NSFL1C;YOD1;RAD23B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H