General Information of Drug (ID: DMWC6RU)

Drug Name
SKF-83959 Drug Info
Synonyms SKF83959; SKF 83959
Cross-matching ID
PubChem CID
133538
ChEBI ID
CHEMBL574558
CAS Number
CAS 80751-85-5
TTD Drug ID
D0L3MJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Proximal tubule bicarbonate reclamation 1.85 1.09e-1 21/23 (91.3%) CA2;CA4;AQP1;...
PPAR signaling pathway 1.80 7.91e-2 66/74 (89.19%) PLIN1;ACSL1;PPARG;...
Nicotine addiction 1.78 6.26e-2 32/40 (80%) GABRE;GABRA1;SLC17A7;...
Other types of O-glycan biosynthesis 1.69 1.41e-1 29/47 (61.7%) RFNG;GALNT12;GALNT7;...
Regulation of lipolysis in adipocytes 1.64 1.86e-1 52/55 (94.55%) PLIN1;GNAS;FABP4;...
Nitrogen metabolism 1.63 1.66e-1 16/17 (94.12%) CA2;CA4;CA3;...
Gastric acid secretion 1.62 1.72e-1 63/76 (82.89%) GNAS;CA2;ATP1A2;...
IL-17 signaling pathway 1.62 1.51e-1 84/94 (89.36%) CXCL8;CCL2;LCN2;...
Vasopressin-regulated water reabsorption 1.60 1.60e-1 40/44 (90.91%) GNAS;RAB5B;DYNC1I1;...
Pancreatic secretion 1.60 1.44e-1 87/102 (85.29%) GNAS;CA2;PLA2G2A;...
Dilated cardiomyopathy 1.57 1.54e-1 86/96 (89.58%) GNAS;TPM2;ITGB4;...
Adipocytokine signaling pathway 1.55 1.76e-1 64/69 (92.75%) ACSL1;ADIPOQ;PCK1;...
Bladder cancer 1.54 1.81e-1 40/41 (97.56%) CXCL8;FGFR3;ERBB2;...
Bile secretion 1.54 1.71e-1 68/90 (75.56%) GNAS;CA2;AQP1;...
Non-homologous end-joining 1.53 1.61e-1 11/13 (84.62%) DNTT;RAD50;LIG4;...
Mucin type O-glycan biosynthesis 1.53 1.61e-1 20/36 (55.56%) GALNT12;GALNT7;GALNT1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.48 2.28e-1 62/70 (88.57%) CXCL8;PAK1;MAPK10;...
Steroid hormone biosynthesis 1.46 2.65e-1 43/61 (70.49%) AKR1C2;AKR1C1;HSD17B6;...
ECM-receptor interaction 1.45 2.64e-1 80/88 (90.91%) ITGB4;COL6A1;COL4A5;...
Proteoglycans in cancer 1.44 2.65e-1 172/205 (83.9%) CAV2;PAK1;PLAUR;...
Hypertrophic cardiomyopathy 1.43 2.74e-1 81/90 (90%) TPM2;ITGB4;DMD;...
Phenylalanine metabolism 1.43 2.66e-1 14/17 (82.35%) MAOA;AOC3;ALDH3A1;...
Fatty acid biosynthesis 1.41 2.96e-1 16/18 (88.89%) ACSL1;FASN;ACSL3;...
Central carbon metabolism in cancer 1.41 2.92e-1 67/70 (95.71%) FGFR3;HIF1A;LDHB;...
AMPK signaling pathway 1.40 2.84e-1 106/120 (88.33%) PPARG;ADIPOQ;SCD;...
Focal adhesion 1.38 3.06e-1 180/201 (89.55%) CAV2;PAK1;ITGB4;...
alpha-Linolenic acid metabolism 1.38 3.02e-1 17/25 (68%) PLA2G2A;PLAAT3;ACOX1;...
Tight junction 1.38 2.98e-1 130/169 (76.92%) AMOTL2;MYH11;CLDN10;...
Thiamine metabolism 1.38 2.90e-1 12/15 (80%) AK4;ALPP;AK5;...
Cocaine addiction 1.38 2.81e-1 42/49 (85.71%) GNAS;MAOA;CDK5R1;...
RNA transport -1.14 6.25e-1 128/186 (68.82%) EIF2B4;FMR1;EIF4A1;...
Acute myeloid leukemia -1.16 6.09e-1 66/67 (98.51%) PIK3R1;TCF7L1;RUNX1;...
Coronavirus disease -1.16 6.21e-1 215/232 (92.67%) MASP2;MAPK14;RSL24D1;...
Vitamin digestion and absorption -1.17 6.05e-1 17/24 (70.83%) APOA4;SCARB1;APOB;...
Hematopoietic cell lineage -1.17 6.12e-1 90/99 (90.91%) GP5;IL1R2;GYPA;...
Spinocerebellar ataxia -1.17 6.06e-1 128/143 (89.51%) PSMD7;ADRM1;AFG3L2;...
Staphylococcus aureus infection -1.18 6.15e-1 72/95 (75.79%) MBL2;DEFA5;HLA-DOA;...
C-type lectin receptor signaling pathway -1.19 5.83e-1 93/104 (89.42%) STAT1;BCL10;MAPKAPK2;...
Metabolism of xenobiotics by cytochrome P450 -1.20 5.85e-1 49/77 (63.64%) ADH7;GSTO1;GSTT2;...
Glutathione metabolism -1.20 5.95e-1 43/57 (75.44%) ANPEP;GSTO1;GSTT2;...
Lysosome -1.20 5.90e-1 115/128 (89.84%) PLA2G15;CTSW;TPP1;...
Allograft rejection -1.20 6.01e-1 32/38 (84.21%) HLA-F;FASLG;IL10;...
Drug metabolism -1.21 6.11e-1 78/151 (51.66%) GUSB;CYP2C8;ADH7;...
Pertussis -1.21 6.06e-1 64/76 (84.21%) LY96;JUN;MYD88;...
Tryptophan metabolism -1.21 6.17e-1 35/42 (83.33%) KYNU;TDO2;DHTKD1;...
Various types of N-glycan biosynthesis -1.25 6.19e-1 26/39 (66.67%) MAN1A2;DDOST;CHST8;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.28 6.07e-1 79/89 (88.76%) HRAS;JUN;MAP2K3;...
Synthesis and degradation of ketone bodies -1.28 6.21e-1 9/10 (90%) BDH1;ACAT1
Cortisol synthesis and secretion -1.32 6.18e-1 58/65 (89.23%) ADCY8;ADCY9;AGT;...
Thyroid cancer -1.33 6.08e-1 36/37 (97.3%) RXRA;CCDC6;TCF7L1;...
Inflammatory bowel disease -1.35 5.91e-1 58/65 (89.23%) IL5;IFNGR2;HLA-DRB1;...
Cytosolic DNA-sensing pathway -1.35 6.13e-1 52/63 (82.54%) DDX58;POLR3C;POLR2F;...
Legionellosis -1.40 6.00e-1 51/57 (89.47%) ARF1;HSPD1;HSPA1A;...
Aminoacyl-tRNA biosynthesis -1.42 5.96e-1 15/66 (22.73%) TARS2;LARS2;WARS2;...
Fat digestion and absorption -1.43 5.93e-1 35/43 (81.4%) CD36;PLA2G1B;AGPAT2;...
Valine, leucine and isoleucine degradation -1.57 3.24e-1 42/48 (87.5%) AUH;ACADM;PCCB;...
Cholesterol metabolism -1.60 2.89e-1 44/50 (88%) SOAT2;CETP;CD36;...
RNA polymerase -1.71 1.35e-1 23/31 (74.19%) POLR3C;POLR2F;POLR3K;...
Ribosome biogenesis in eukaryotes -1.74 1.47e-1 52/108 (48.15%) CSNK2B;BMS1;RCL1;...
Ribosome -1.80 1.82e-1 113/158 (71.52%) RPS28;RPL4;RPS11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H