Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWGRQD)

Drug Name
LU AE58054 Drug Info
Synonyms
Idalopirdine; Lu AE58054; 467459-31-0; LU-AE58054; UNII-59WCJ0YNWM; LU AE 58054; 59WCJ0YNWM; 2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine; 1H-Indole-3-ethanamine,6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-; 1H-Indole-3-ethanamine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-; Idalopirdine [USAN:INN]; Idlopirdine; Idalopirdine (USAN/INN); Lu AE58054;Idalopirdine; SCHEMBL762762; Idalopirdine(Lu-AE-58054); GTPL8689; CHEMBL3286580; C20H19F5N2O; EX-A844
Cross-matching ID
PubChem CID
21071390
ChEBI ID
CHEMBL3286580
CAS Number
CAS 467459-31-0
TTD Drug ID
D09IRN
INTEDE Drug ID
DR1883

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.02 0.00e+0 19/20 (95%) DHCR24;MSMO1;SC5D;...
Biosynthesis of unsaturated fatty acids 2.02 0.00e+0 21/27 (77.78%) FADS2;SCD;FADS1;...
African trypanosomiasis -1.77 1.78e-2 32/37 (86.49%) THOP1;HPR;ICAM1;...
Graft-versus-host disease -1.78 1.86e-2 32/42 (76.19%) HLA-A;HLA-E;IL6;...
Viral protein interaction with cytokine and cytokine re... -1.91 1.98e-3 84/100 (84%) CCL24;IL18;CCL21;...
Epithelial cell signaling in Helicobacter pylori infect... -1.95 2.37e-3 62/70 (88.57%) IKBKG;CHUK;GIT1;...
Renin-angiotensin system -2.02 2.96e-3 20/23 (86.96%) REN;ENPEP;PREP;...
Rheumatoid arthritis -2.04 3.95e-3 78/93 (83.87%) ATP6V1F;HLA-DRB1;CCL20;...
TNF signaling pathway -2.07 0.00e+0 103/112 (91.96%) FAS;RPS6KA4;BIRC3;...
IL-17 signaling pathway -2.35 0.00e+0 84/94 (89.36%) CSF3;TRAF3IP2;IL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H