Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWHEV8)

Drug Name
[3H]spiperone Drug Info
Synonyms
Spiperone; spiperone; Spiroperidol; Spiropitan; 749-02-0; Espiperona; Spiperonum; [3H]-spiperone; R 5147; Spiperonum [INN-Latin]; Espiperona [INN-Spanish]; E 525; UNII-4X6E73CJ0Q; NSC 170983; MLS000028615; Spiperone [USAN:INN:BAN:JAN]; 8-(3-(p-Fluorobenzoyl)propyl)-1-phenyl-1,3,8-triazaspiro(45)decan-4-one; 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[45]decan-4-one; 8-(3-p-Fluorobenzoyl-1-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decane; EINECS 212-024-0; BRN 0632204; SMR000058674; [3H]-spiperone; SPIPERONE
Cross-matching ID
PubChem CID
5265
ChEBI ID
CHEMBL267930
CAS Number
CAS 749-02-0
TTD Drug ID
D05EQG
VARIDT Drug ID
DR01493

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.56 0.00e+0 127/171 (74.27%) HERPUD1;SEC24D;SEC63;...
Steroid biosynthesis 2.48 0.00e+0 19/20 (95%) MSMO1;NSDHL;CYP51A1;...
Protein export 2.41 0.00e+0 17/23 (73.91%) SEC63;SEC61A1;SRPRB;...
Amino sugar and nucleotide sugar metabolism 1.96 1.71e-3 38/48 (79.17%) GFPT1;NANS;PGM3;...
Ferroptosis 1.89 6.84e-3 36/41 (87.8%) SLC7A11;SLC39A8;ACSL5;...
Terpenoid backbone biosynthesis 1.89 5.70e-3 18/22 (81.82%) IDI1;HMGCS1;HMGCR;...
Synthesis and degradation of ketone bodies 1.77 1.47e-2 9/10 (90%) HMGCS1;ACAT2;HMGCS2;...
T cell receptor signaling pathway -1.62 4.57e-2 93/104 (89.42%) LCP2;SOS1;PIK3R1;...
Platelet activation -1.62 4.69e-2 106/124 (85.48%) FGG;GP1BB;MAPK11;...
Breast cancer -1.63 4.60e-2 119/147 (80.95%) PIK3R2;FRAT2;DVL1;...
Gastric cancer -1.64 4.49e-2 122/149 (81.88%) SMAD3;SOS1;PIK3R1;...
Maturity onset diabetes of the young -1.66 3.17e-2 21/26 (80.77%) PDX1;NKX2-2;HNF1A;...
Th1 and Th2 cell differentiation -1.67 2.93e-2 80/92 (86.96%) STAT5B;HLA-DMB;HLA-DQB1;...
Vascular smooth muscle contraction -1.69 2.79e-2 113/133 (84.96%) PRKCQ;PRKACA;GNA13;...
Glutamatergic synapse -1.69 2.72e-2 97/114 (85.09%) DLG4;PLCB2;SLC17A6;...
DNA replication -1.70 2.17e-2 34/36 (94.44%) LIG1;RFC2;PRIM1;...
Adherens junction -1.71 2.22e-2 63/71 (88.73%) TCF7L1;EGFR;NECTIN2;...
Gap junction -1.71 2.09e-2 72/88 (81.82%) PLCB2;EGFR;GRM5;...
Notch signaling pathway -1.72 2.23e-2 49/59 (83.05%) TLE6;MAML1;MAML3;...
Nicotine addiction -1.72 2.29e-2 32/40 (80%) GABRD;SLC17A6;GABRB3;...
Rap1 signaling pathway -1.73 2.36e-2 184/210 (87.62%) LCP2;MAGI1;PIK3R1;...
GnRH secretion -1.73 2.56e-2 60/64 (93.75%) CACNA1I;KCNN2;PIK3R1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.75 1.52e-2 49/53 (92.45%) PRKCA;CLTCL1;AP2M1;...
GnRH signaling pathway -1.78 8.38e-3 80/93 (86.02%) MAP2K2;MAP2K6;PRKCA;...
Hippo signaling pathway -1.82 9.31e-3 120/186 (64.52%) PPP1CB;BMP7;DLG4;...
Signaling pathways regulating pluripotency of stem cell... -1.82 1.05e-2 110/143 (76.92%) TBX3;NANOG;FZD3;...
Pancreatic secretion -1.84 7.98e-3 87/102 (85.29%) ATP2B4;RAB3D;ITPR1;...
Morphine addiction -1.85 6.98e-3 80/91 (87.91%) GRK5;GNB5;PDE1B;...
Long-term depression -1.92 5.59e-3 55/60 (91.67%) LYN;PLCB2;GNAO1;...
Circadian entrainment -1.99 3.49e-3 85/97 (87.63%) CREB1;ADCYAP1;PER1;...
Oxytocin signaling pathway -2.00 4.65e-3 128/154 (83.12%) CACNG3;CACNB4;ROCK2;...
Cell cycle -2.08 6.98e-3 110/124 (88.71%) CDC14B;PTTG1;E2F4;...
Gastric acid secretion -2.09 1.40e-2 63/76 (82.89%) ATP4A;PLCB2;CAMK2B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H, 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H